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  • Posts

    • bongme
      hi   GW Pharmaceuticals and the cannabis biotech firms   From Australia to the UK, companies are using compounds found in cannabis as ingredients in medicinal drugs.       Before the rise of the Canadian unicorns, a secret location in southeast England was said to be the largest legal cannabis growing site in the world. Founded by two British doctors, GW Pharmaceuticals [GWPH] has produced hundreds of tonnes of cannabis at its guarded site since launching in 1998.
       
      Despite the UK announcing plans only in July to allow doctors to prescribe a wide range of medicines made from cannabis, the government has already handed out swathes of licences for growing the drug. In 2010, almost a decade before the US, the British government was also one of the first to approve a medicine that contains marijuana: GW’s Sativex, a spray used to treat symptoms related to multiple sclerosis. GW made history again in 2018 when another drug it produces became the first to contain naturally derived cannabis to be approved by the FDA in the US.    An industry in development
      With a growing number of international licences and new drugs in the pipeline, many are extremely bullish on GW’s outlook. The company was up by 40% over the past year, and 1,500% since floating on the NASDAQ in 2013. Before GW, cannabis pharmaceuticals in the US had been dominated by companies that worked around prohibition by synthesising the effects of cannabis. Established companies with a range of medicines such as AbbVie [ABBV], Corbus Pharmaceuticals [CRBP], Cara Therapeutics [CARA], and Insys Therapeutics [INSY] have all developed drugs using an artificial cannabinoid that was first approved by the FDA in 1985. With these companies having a hold on a synthetic form that has already been produced, distributed and marketed, it’s perhaps not surprising that many are against legalising the natural stuff: Insys Therapeutics, which has lost 82% of its value since 2015, has spent $500,000 lobbying against the legalisation of cannabis in Arizona. Therapix Biosciences [TRPX] – a company set up to develop medicines from the synthetic THC form – has also suffered over the past year, losing nearly half of its value.    Diversifying the market
      Aside from GW, other companies concentrating on producing medicines from naturally occurring cannabinoids include Australia’s Medlab Clinical [MDC] and Zelda Therapeutics [ZLD]. The existing biotech companies operating in this space live in a very different world and offer a completely alternative proposition to the market than medical marijuana growers and distributors in the US or Canada. With regulatory approval, they function as any other pharmaceutical company, and are at far less risk from changes in laws.
       
      It might be one reason why Canada’s largest cannabis producer, Canopy Growth [CGC], is also now setting its sights on medicines. According to Bruce Linton, the company’s CEO, it plans to “completely disrupt the pharmaceuticals industry, from sleep to oncology”. Canopy Growth recently started clinical trials in Canada, where it is investigating how different combinations of molecules found in cannabis can be used to treat a variety of illnesses. It is also part of a “multi-million pounds” joint venture in the UK with Lady Amanda Feilding’s Beckley Foundation. If successful, Canopy Growth will become the first plant seller to properly cross over into the pharmaceutical industry.   https://www.cmcmarkets.com/en-gb/opto/gw-pharmaceuticals-and-the-cannabis-biotech-firms   Bongme     
    • HeavySmoker
      Damn they do look nice

      I will be looking to upgrade in a few months
    • bongme
      hi   Marijuana's effects linger for 24 hours: Study finds users struggle to retain new information for a day after indulging   Daily Mail   Finally, scientists can answer the question everyone who has ever gotten too high has been dying to know: 'how long will this last?'  It's still a range, but University of Alberta researchers discovered that cannabis still impairs learning up to 24 hours after consumption - but the effects dissipate fully by the third day.   The team tested how long cannabis would change their study participants' ability to learn new information.  Much remains to be studied, but their research provides a starting point for the Canadian government to establish safety guidelines, now that the country has legalized marijuana.      Canada has been hard at work preparing for nationwide cannabis legalization.  Lead study author, Dr Scot Purdon says that for the last year, Canada has had its watchful eye on US states like Colorado, California and Washington, learning from their successes (and mistakes).  But marijuana's cognitive effects are more complicated and subtle than those from alcohol, and we don't yet have a particularly good way to test, for example, drivers for it.   Dr Purdon has made it his mission to work out what weed does to the brain - and for how long.     We know that cannabis can 'have very significant psychological and cognitive effects,' he told Daily Mail online.  These effects are particularly obvious in the memory, learning and verbal abilities of someone who has recently used cannabis.  So Dr Purdon and his team decided to test these abilities in 120 young people who were frequent users.  He an his team administered the students verbal learning and fluency standardized tests and before and after they used marijuana.    Unsurprisingly, the subjects struggled on these tests in the hours immediately following their cannabis consumption.  But even 48 later, people may still make mistakes they wouldn't have sober. By 72 hours after cannabis consumption though, people should well back to their baseline, Dr Purdon said, leading him to suggest this could be a good time limit standard for people to return to jobs. Of course, everyone metabolizes marijuana somewhat differently, and heavy users may even have signs of marijuana in their urine after 28 days.  Dr Purdon also says that his research also clarifies some common notions about marijuana, such as the idea that it makes people more focused.  'A lot of people tell us it's a positive thing [for concentration], but the data don't always bear that out,' he says.  'Its complicated, in that [high] people don't have the distractability that might be necessary in day-to-day functioning. You get so focused on A that you don't notice B, C and D around you.'  And focused or not, his research subjects simply didn't retain or recall information as well within the first couple of days after using cannabis, which is especially pertinent to students who be tempted to light up a joint as a study aid or study break.  Though his research did not examine how long after smoking, eating or vaping weed people were capable of driving cars, it could become important to Canada's laws surrounding road safety and marijuana.  In 2016, marijuana was involved in more fatal car accidents in the US than alcohol was, sparking calls from officials for better testing and stricter laws.  Dr Purdon says that Canada's broad legalization of marijuana is an 'experiment on 33 million people,' and hopes that, now that it's a legal substance, there will be more control over its potency, and greater clarity about how high high is too high - and for how long.          https://www.dailymail.co.uk/health/article-6296011/Marijuana-impairs-thinking-24-HOURS-using-study-finds.html   Bongme           
    • Phoenix
      Stop touching that one.  If anything mist it lightly with water to keep the shell/membrane soft.  The plant usually does the rest by itself.  Only on the very odd occasion is our meddling truly required!