[elysium]

I've done a little research into activating cannabinoid receptors. May well be useful info.

Activating Cannabinoid Receptors
April 2012


Cannabinoid therapy appears to works marvelously for some, and yet others fail to respond.

Whilst it is critical to consider cannabinoid content as a factor in this (i.e. – Is there enough Cannabidiol (CBD) in your extract? Etc. Another mitigating detail lies within if ones cannabinoid receptors are activated or not.

Methylation has been proven to deactivate CB receptors, and this appears particularly prevalent within cancers of the stomach, colon1 and breast.

If methylation can create such an unwanted and critical scenario during cannabinoid therapy, then those undergoing cannabinoid therapy should look to include demethylating2 agents into their regime.

These include; Green Tea, FeverFew and Annurca Apples3
Green Tea is particularly useful as it can also naturally create Anti-Angiogenesis4

Another area that should be explored is within the use of Phenolic Oils.

Phenols and Phenylpropanoids are compounds of carbon-ring molecules incorporating on isoprene unit. They are sometimes called hemiterpenes. There are dozens of varieties of phenylpropanoids. They are found in Clove (90%), Cassia (80%), Basil (75%), Cinnamon (73%), Oregano (60%), Anise (50%), and Peppermint (25%).

While they can create conditions where unfriendly viruses and bacteria cannot live, the most important function performed by phenylpropanoids is that they clean the receptor sites on the cells. Without clean receptor sites cells cannot communicate, and the body malfunctions, resulting in sickness.

David Stewart, PhD, DNM also suggests in his book 'The Chemistry of Essential Oils Made Simple’ – that phenolic oils can clean receptor sites.

Prof. Dr. Jürg Gertsch of the Institute of Biochemistry and Molecular Medicine, Switzerland conducted a brilliant research paper5 looking for Phytocannabinoids beyond cannabis.

Prof Jürg Gertsch was kind enough to suggest the essential oil of Melissa officinalis (Lemon Balm) due to its terpenoid content, as a way to activate CB receptors, based on some preliminary research he has conducted.


1 http://www.scienceda...80801074056.htm
2 http://www.anti-agin...ing-at-cancers/
3 http://jn.nutrition....37/12/2622.full
4 http://www.alternati...cancer-natural/
5 http://www.ncbi.nlm....les/PMC2931553/

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[MED]

fantastic post many thanks for sharing your work

greentea on the shopping list now

can i ask a question about the receptors? you mention only cannabinoid receptors. am i wrong in thinking thats the same receptors THC interacts with?

[groovelick]

 MED, on 21 April 2012 - 11:01 AM, said:

fantastic post many thanks for sharing your work

greentea on the shopping list now

can i ask a question about the receptors? you mention only cannabinoid receptors. am i wrong in thinking thats the same receptors THC interacts with?

I think you are a little confused cannabinoid is the group descriptor ie THC CBD CBN, its easy to get CBD (Cannabidiol) confused with cannabinoid.

[MED]

 groovelick, on 21 April 2012 - 11:20 AM, said:

 MED, on 21 April 2012 - 11:01 AM, said:

fantastic post many thanks for sharing your work

greentea on the shopping list now

can i ask a question about the receptors? you mention only cannabinoid receptors. am i wrong in thinking thats the same receptors THC interacts with?

I think you are a little confused cannabinoid is the group descriptor ie THC CBD CBN, its easy to get CBD (Cannabidiol) confused with cannabinoid.

ah cheers groovelick i forget more than i learn

edit 2 say,.. so it is the same receptors then?

nuh hold on. i wasnt confusing cannabidiol with cannabinoids just clearing up for myself that they are the same receptors.

This post has been edited by MED: 21 April 2012 - 11:33 AM

[twigs]

 elysium, on 21 April 2012 - 10:50 AM, said:

I've done a little research into activating cannabinoid receptors. May well be useful info.

Activating Cannabinoid Receptors
April 2012


Cannabinoid therapy appears to works marvelously for some, and yet others fail to respond.

Whilst it is critical to consider cannabinoid content as a factor in this (i.e. – Is there enough Cannabidiol (CBD) in your extract? Etc. Another mitigating detail lies within if ones cannabinoid receptors are activated or not.

Methylation has been proven to deactivate CB receptors, and this appears particularly prevalent within cancers of the stomach, colon1 and breast.

If methylation can create such an unwanted and critical scenario during cannabinoid therapy, then those undergoing cannabinoid therapy should look to include demethylating2 agents into their regime.

These include; Green Tea, FeverFew and Annurca Apples3
Green Tea is particularly useful as it can also naturally create Anti-Angiogenesis4

Another area that should be explored is within the use of Phenolic Oils.

Phenols and Phenylpropanoids are compounds of carbon-ring molecules incorporating on isoprene unit. They are sometimes called hemiterpenes. There are dozens of varieties of phenylpropanoids. They are found in Clove (90%), Cassia (80%), Basil (75%), Cinnamon (73%), Oregano (60%), Anise (50%), and Peppermint (25%).

While they can create conditions where unfriendly viruses and bacteria cannot live, the most important function performed by phenylpropanoids is that they clean the receptor sites on the cells. Without clean receptor sites cells cannot communicate, and the body malfunctions, resulting in sickness.

David Stewart, PhD, DNM also suggests in his book 'The Chemistry of Essential Oils Made Simple’ – that phenolic oils can clean receptor sites.

Prof. Dr. Jürg Gertsch of the Institute of Biochemistry and Molecular Medicine, Switzerland conducted a brilliant research paper5 looking for Phytocannabinoids beyond cannabis.

Prof Jürg Gertsch was kind enough to suggest the essential oil of Melissa officinalis (Lemon Balm) due to its terpenoid content, as a way to activate CB receptors, based on some preliminary research he has conducted.


1 http://www.scienceda...80801074056.htm
2 http://www.anti-agin...ing-at-cancers/
3 http://jn.nutrition....37/12/2622.full
4 http://www.alternati...cancer-natural/
5 http://www.ncbi.nlm....les/PMC2931553/

very interesting

thanks for that..

[groovelick]

 MED, on 21 April 2012 - 11:25 AM, said:

 groovelick, on 21 April 2012 - 11:20 AM, said:

 MED, on 21 April 2012 - 11:01 AM, said:

fantastic post many thanks for sharing your work

greentea on the shopping list now

can i ask a question about the receptors? you mention only cannabinoid receptors. am i wrong in thinking thats the same receptors THC interacts with?

I think you are a little confused cannabinoid is the group descriptor ie THC CBD CBN, its easy to get CBD (Cannabidiol) confused with cannabinoid.

ah cheers groovelick i forget more than i learn

edit 2 say,.. so it is the same receptors then?

Yep same receptors

[datadude]

great post, thanks dude.

data.

[landsker]

Thanks there, Elysium, it`s really good to read science-based pieces about human metabolism and cannabis.

[Graywolf]

 elysium, on 21 April 2012 - 10:50 AM, said:

I've done a little research into activating cannabinoid receptors. May well be useful info.

Activating Cannabinoid Receptors
April 2012

Excellent post and good ideas bro!

[yddraig]

Really good post elysium, some very important information that I wasn't aware of before, and backed up with proper references. Excellent stuff

[elysium]

No problem guys ...

Thanks goes to Graywolf for bringing to light the work of David Stewart.

My research into this will be ongoing- so I'll update as and when and post it here.

[Chris P]

Thanks for posting, had a bit of a read earlier.

It's interesting that you can buy from any supermarket something that inhibits the main enzyme that breaks down cannabinoids in the liver.

I will be bang on that when my crop finishes to try to make it last til next harvest. Cannabis potentiator? Yes please

[curiositymike]