Diabetes and Cannabis
Posted 21 March 2012 - 04:46 PM
Unfortunately you can only get at the abstract and editorial summary on this one, unless you have a paid subscription.
When I look for more information, however, I find conflicting reports. Some say cannabis is a good treatment for diabetes. NORML, for example, reporting those mixed results, says that CBDs reduce incidence of diabetes in mice.
Hmm. This one says that cannabis use in the UK is declining. Is that so? Anyhow, looks equivocal once again, but again only registered users of the site can see the whole article. http://www.medscape....warticle/738863
AAMC also reports contradictory evidence, but seems to emphasize the positive a little more. http://www.letfreedo.../diabetes_5.htm
With the jury out on cannabis treatment for diabetes, does anyone here have anecdotal evidence? Got diabetes and noticed any effects, positive or negative, from cannabis use?
I don't have diabetes myself but may have a genetic predisposition, so I'm going to go with the CBD lab mice for now and hope cannabis' preventative powers are on my side.
Posted 21 March 2012 - 07:53 PM
I've never noticed smoking have much effect on my blood glucose levels one way or the other. I lost the bookmark in a system crash but there was an article cited on here showing that CBD could ameliorate the chemical reactions associated with retina damage in diabetics with retinopathy.
Whatever this 'pharmacological blockade' of the receptors is, I would hope it was specific to the pancreas since a general attack on all the receptors in all organs could play havoc, as well as reducing one's ability to get stoned !
Posted 21 March 2012 - 08:17 PM
Edit: I'm a type 1 too
This post has been edited by Tuzio: 21 March 2012 - 08:18 PM
Posted 21 March 2012 - 08:39 PM
CANNABIS AND DIABETES
Cannabidiol Preserves Retinal Neurons and Reduces Vascular Permeability in Experimental Diabetes (abst - 2004)
The effect of WIN 55,212-2, a cannabinoid agonist, on tactile allodynia in diabetic rats.
(abst – 2004) http://www.ncbi.nlm....pubmed/15519750
Cannabidiol lowers incidence of diabetes in non-obese diabetic mice (full - 2005) http://www.ncbi.nlm....?tool=pmcentrez
Activation of the Peripheral Endocannabinoid System in Human Obesity
(full - 2005) http://www.ncbi.nlm....?tool=pmcentrez
Gpr40 Gene Expression in Human Pancreas and Insulinoma. (abst – 2005)
The Ffa Receptor Gpr40 Links Hyperinsulinemia, Hepatic Steatosis, and Impaired Glucose Homeostasis in Mouse. (abst – 2005)
Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes (full - 2006) http://www.ncbi.nlm....72/?tool=pubmed
Regulation, Function, and Dysregulation of Endocannabinoids in Models of Adipose and ß-Pancreatic Cells and in Obesity and Hyperglycemia (full - 2006)
Weight Control in Individuals With Diabetes (full - 2006)
Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration. (abst – 2006) http://www.ncbi.nlm....pubmed/17011761
Expression of the Gene for a Membrane-bound Fatty Acid Receptor in the Pancreas and Islet Cell Tumours in Humans: Evidence for Gpr40 Expression in
Pancreatic Beta Cells and Implications for Insulin Secretion. (abst – 2006)
The Cannabinergic System as a Target for Anti-inflammatory Therapies
(abst - 2006) http://www.ingentaco...000013/art00008
Non-Psychoactive Cannabinoid Reduces Incidence Of Diabetes, Study Says
(news - 2006) http://www.norml.org...m?Group_ID=6909
Marijuana Compound May Help Stop Diabetic Retinopathy (news - 2006)
Cannabidiol, a marijuana compound, may help stop diabetic retinopathy (news – 2006)
Marijuana Compound Offers Hope In Diabetic Retinopathy Prevention (news – 2006)
Cannabidiol reduces the development of diabetes in an animal study (news - 2006)
Getting Eye On Cannabinoids (news - 2006)
Marijuana compound could prevent eye damage in diabetics (news - 2006)
Cannabidiol arrests onset of autoimmune diabetes in NOD mice (full - 2007)
Expression of Cannabinoid CB1 Receptors in Models of Diabetic Neuropathy
(full - 2007)
Cannabidiol attenuates high-induced endothelial cell inflammatory response and barrier disruption (full - 2007) http://www.pubmedcen...&tool=pmcentrez
US Patent Application 20070099987 - Treating or preventing diabetes with cannabidiol
(full – 2007) http://www.patentsto...7/fulltext.html
Role of cannabinoid CB2 receptors in glucose homeostasis in rats (abst – 2007)
The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells (abst - 2007) http://lib.bioinfo.pl/pmid:17604177
Anticoagulant Effects of a Cannabis Extract in an Obese Rat Model (abst - 2007)
Mediation of Cannabidiol anti-inflammation in the Retina by Equilibrative Nucleoside Transporter and A2A Adenosine Receptor (full - 2008) http://www.ncbi.nlm....?tool=pmcentrez
The Role of Adipocyte Insulin Resistance in the Pathogenesis of Obesity-Related Elevations in Endocannabinoids (full – 2008)
GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity (full - 2008) http://www.ncbi.nlm....?tool=pmcentrez
Endocannabinoid Dysregulation in the Pancreas and Adipose Tissue of Mice Fed With a High-fat Diet (full - 2008) http://www.nature.co...by2007106a.html
Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation. (full - 2008) http://www.ncbi.nlm....95/?tool=pubmed
Endocannabinoids and the Control of Energy Homeostasis (full – 2008)
Mediation of Cannabidiol Anti-inflammation in the Retina by Equilibrative Nucleoside Transporter and A2A Adenosine Receptor (full – 2008) http://www.iovs.org/...49/12/5526.full
Presence of functional cannabinoid receptors in human endocrine pancreas. (abst – 2008)
Cannabidiol As a Putative Novel Therapy for Diabetic Retinopathy: A Postulated Mechanism of Action as an Entry Point for Biomarker-Guided Clinical Development. (full - 2009) http://www.ncbi.nlm....20/?tool=pubmed
Cannabinoids as novel anti-inflammatory drugs. (full - 2009)
Cannabinoid CB2 Receptor Potentiates Obesity-Associated Inflammation, Insulin Resistance and Hepatic Steatosis (full - 2009) http://www.ncbi.nlm....60/?tool=pubmed
The endocanabinnoid system and diabetes - critical analyses of studies conducted with rimonabant (full - 2009) http://www.ncbi.nlm....?tool=pmcentrez
Biological effects of THC and a lipophilic cannabis extract on normal and insulin resistant 3T3-L1 adipocytes (abst - 2009)
Anti-inflammatory effect of palmitoylethanolamide on human adipocytes. (abst – 2009)
Beneficial effects of a Cannabis sativa extract on diabetes induced neuropathy and oxidative stress. (abst - 2009)
Cannabis plant extracts could potentially form the basic ingredients for a market-leading diabetes drug (news – 2009)
Expression and function of cannabinoid receptors in mouse islets. ( full – 2010)
Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain (full - 2010)
Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. (full - 2010) http://www.ncbi.nlm....48/?tool=pubmed
Cannabinoid Receptor 1 Blockade Ameliorates Albuminuria in Experimental Diabetic Nephropathy (full – 2010)
Cannabinoid Receptors are Coupled to Stimulation of Insulin Secretion from Mouse MIN6 β-cells (full – 2010)
Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients (full - 2010) http://www.lipidworl.../content/9/1/43
Cannabinoid receptor stimulation impairs mitochondrial biogenesis in mouse white adipose tissue, muscle, and liver: the role of eNOS, p38 MAPK, and AMPK pathways.
(full – 2010) http://diabetes.diab...826.long#sec-25
Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes. (full - 2010) http://www.ncbi.nlm....07/?tool=pubmed
Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy
(full - 2010) http://www.natap.org...s/marijuana.pdf
Rehashing endocannabinoid antagonists: can we selectively target the periphery to safely treat obesity and type 2 diabetes? (full – 2010) http://www.jci.org/a...ew/44099?search[abstract_text]=&search[article_text]=cannabinoid& search[authors_text]=&search[fpage]=&search[title_text]=&search[volume]=
Novel GPR119 agonist AS1535907 contributes to first-phase insulin secretion in rat perfused pancreas and diabetic db/db mice. (abst – 2010) http://www.ncbi.nlm....pubmed/20937249
AS1907417, a novel GPR119 agonist, as an insulinotropic and β-cell preservative agent for the treatment of type 2 diabetes. (abst – 2010) http://www.ncbi.nlm....pubmed/20816753
Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age. (abst – 2010) http://www.springerl...37q1lh40l15161/
GPR119 agonists for the potential treatment of type 2 diabetes and related metabolic disorders. (abst – 2010) http://www.ncbi.nlm....pubmed/21094910
Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation.
(abst – 2010)
Pot Compound Mitigates Diabetic Cardiomyopathy (news - 2010)
Cannabinoids inhibit and may prevent neuropathic pain in diabetes. (news - 2010)
Lab Notes: Pot Has Benefits for Diabetic Hearts (news - 2010)
Cannabinoid receptor 2 signaling does not modulate atherogenesis in mice (full– 2011)
Role for cannabinoid receptors in human proximal tubular hypertrophy. (full– 2011)
Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. (abst – 2011) http://www.unboundme...cardiomyopathy_
Central Endocannabinoid Signaling Regulates Hepatic Glucose Production and Systemic Lipolysis (abst – 2011) http://diabetes.diab...4/1055.abstract
Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells (abst – 2011)
Acute cannabinoid receptor type 1 (CB1R) modulation influences insulin sensitivity by an effect outside the central nervous system in mice. (abst – 2011) http://www.ncbi.nlm....pubmed/21340622
Cannabinoid receptor agonists and antagonists stimulate insulin secretion from isolated human islets of Langerhans. (abst – 2011)
A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans.
(abst – 2011) http://www.ncbi.nlm....pubmed/21885477
Protective Role of Cannabinoid Receptor Type 2 in a Mouse Model of Diabetic Nephropathy. (abst – 2011) http://www.ncbi.nlm....pubmed/21810593
Cannabinoids and Endocannabinoids in Metabolic Disorders with Focus on Diabetes. (abst – 2011)
Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. (abst – 2011) http://www.ncbi.nlm....pubmed/21238581
Win 55,212-2 reduces cardiac ischaemia-reperfusion injury in zucker diabetic fatty rats: role of cb2 receptors and cardiac inos/enos expression. (abst – 2011)
GPR119 Regulates Murine Glucose Homeostasis Through Incretin Receptor-Dependent and Independent Mechanisms (abst – 2011)
Cannabidiol Dampens Streptozotocin-Induced Retinal Inflammation by Targeting of Microglial Activation (abst - 2011)
The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119. (abst – 2011) http://www.ncbi.nlm....pubmed/22029844
The Endocannabinoid System: Plant-Derived Cannabinoids in Diabetes and Diabetic Complications. (abst – 2011) http://www.ncbi.nlm....pubmed/22155112
Takeda moves potential first-in-class diabetes drug into phase III (news – 2011)
This post has been edited by twigs: 21 March 2012 - 08:40 PM
The lethal dose ratio (LD-50) for cannabis is estimated to be around 1:20,000 to 1:40,000 which means you have to consume 20,000 to 40,000 times as much cannabis as is contained in one cannabis joint to induce death. This means you would have to consume something like 1,500 lbs in 15 minutes to induce a lethal response. There are no known fatalities from the substance and it is considered non- toxic...
...''First they ignore you; then they mock you; then they punish you; then you win."
Posted 21 March 2012 - 10:25 PM
He finds it is a mixture of things that cause him to become ill.
Due to smoking cannabis he gets the munchies and he ends out eating lots of sugary and fatty foods, Sweets, Take Aways ect ect
He ends out drinking fizzy juices and cups of tea with sugar in them because he gets very thirsty
Due to him being stoned He forgets to take his insulin or gets to Lazy and doesnt bother with it.
He has only been taking insulin for 2 years and became a diabetic in his Adult life. So he finds it very hard to be a Stoner and a Diabetic as he just wants to sit about and get wasted, eating and drinking what ever he wants and also wanting to forget about having to jag his stomach to get insulin in to him
He gets un well from eating loads of sugary foods and not taking his insulin and we have to take him to hospital
The doctors always tell him that the cannabis is making his kidneys work hard and makes him want to drink more. They say this is what makes him so ill so quickly
I think I would also find it hard adjusting to life as a Diabetic
Posted 21 March 2012 - 11:07 PM
This link doesn't give any specifics on how the study was conducted.
Remind me, next life, study biochemistry and don't get too ill to read. I'd love to be able to read all those links, and understand them, twigs.
Posted 21 March 2012 - 11:19 PM
NJD, your mate needs to keep up to testing his blood glucose before he does anything and drink diet fizz or use sweeteners.
It's the emotional burden it puts on you that does the most damage,at first it seems like a constant pain in the ass you can't see why you have to endure. I hope he manages to get used to it. Know how he feels, sugary foods seem like a drug in themselves.
That's a new one to me, I always thought the kidneys worked harder trying to expel excess sugar. High blood sugar leads to high blood pressure, which is bad for the kidneys. Sugar is acid and having high average sugar for years can corrode things like the fine tubules in the kidneys.
Posted 21 March 2012 - 11:45 PM
Drinking sugary drinks will make him even more thirsty, plus anything with straight glucose in them should be avoided unless it's accompanied with less bioavailable food (like protein, fats, or more complex carbs)
I'm probably quick in my judgement, but that's insane. While his cells will starve, the sugar will sit in his blood, making it thick and acidic. The body will then have to resort to fats, whose byproduct is ketones, which will make the blood even more acidic. Nerves, liver, kidneys will suffer and he will get dehydrated as the body will have to use whatever water it can find to get rid of the excess sugar right away - You'll recognise this as he will hit the loo every 10 minutes.
Doctors can be pretty superficial when they train people who have been just diagnosed with diabetes. One very useful thing that your friend can do is train himself to assess the amount of carbs he's eating, this way: putting all the stuff he's going to eat for a meal together, "guestimating" how many units of insulin that corresponds to, then actually calculating it (by looking at the pack or looking up resources over the internet). In a few months this training will allow him to look at *anything* and just know right on the spot how much he needs to inject for it. Another very useful thing is learning how to recognise the symptoms of both excessive and insufficient blood sugar - when I'm too high I get irritable and my stomach gets upset, when I'm too low my pressure drops, I feel anxious and I crave sweets (up until the point I tremble and start proper freaking out)
refuse to make him smoke until he's got his food carb counted - you don't want to police him of course, but he should not make you responsible for his wellbeing if he "can't be bothered". It's a very irresponsible attitude.
After 5 and 1/2 years with the disease I can confidently tell you that the doctors and diabetic nurses contradict one another and say a lot of shit that doesn't make much sense. Diabetes is not an exact science. He shouldn't avoid sugar or carbohydrates, it's literally impossible (also, he would probably die) - but he needs to inject the right amount of insulin for *any carbohydrates he eats*, or he risks getting gastroparesis (a horrible neurodegenerative complication that makes your stomach stop digesting, and they'll fit him a feeding tube for him to eat every single time), blindness (sudden, not a bit at a time, the retina detatches and you're fucked), kidney failure (they'll regularly have to clean up your blood through a machine, it's called dialysis and it's extremely unpleasant), amputation of the feet, and more. He absolutely needs to get it sorted.
Probably, after two years, you wouldn't. The trouble for a diabetic is not the injections, it's mainly psychological - people not understanding your situation or looking at him weird when he injects, having to jump through hoops in order to obtain medication, or even just the thought of no longer being independent from "the system". Give your mate all the support you can, but he absolutely needs to pull his head out of his arse before he ruins his life and face his problem. Diabetes won't go away just because he throws temper tantrums. Suggest to him to get on a diabetic forum, that helps really really much.
Best of luck to your friend, dude.
Posted 22 March 2012 - 07:43 PM
(I hope nobody has already posted this, if so, sorry!).
Edit #1: Whoops! Screwed that one up nicely. Having a look for the right one now.
Edit #2: Here is the actual full article: http://goo.gl/PvyuT
What a way to do a first post.
This post has been edited by bogcotton: 22 March 2012 - 07:52 PM
Posted 22 March 2012 - 08:02 PM
So this article could explain why.
Posted 22 March 2012 - 09:08 PM
I allways get thirsty when smkoing and drink way more stooned.
that's because it lowers your pressure. Being thirsty is no evidence of kidney damage. Eating sugar, fat or salt makes you thirsty, but I have never heard of that being bad for the kidneys (if you do it in moderation, of course).
Posted 23 March 2012 - 01:56 PM
So this article could explain why.
I think that's just you being well controlled and having low blood sugar a lot. It's pretty well the same thing as non-diabetics getting the munchies, which is probably something to do with smoking triggering insulin release or something and could be taken as evidence for smoking being good for diabetics.
Posted 23 March 2012 - 02:47 PM
So this article could explain why.
I'm the same. But I find that all I need is a *little* something sweet immediately after smoking and a pint of water. I avoid smoking on an empty stomach. Sativas seem to affect blood sugar more than Indicas.