[Merrytricks]

A new study shows that cannabis inhibits insulin action. That would be bad news for people with diabetes.
http://stke.sciencem...ourcetype=HWCIT
Unfortunately you can only get at the abstract and editorial summary on this one, unless you have a paid subscription.

When I look for more information, however, I find conflicting reports. Some say cannabis is a good treatment for diabetes. NORML, for example, reporting those mixed results, says that CBDs reduce incidence of diabetes in mice.
http://norml.org/lib...abetes-mellitus

Hmm. This one says that cannabis use in the UK is declining. Is that so? Anyhow, looks equivocal once again, but again only registered users of the site can see the whole article. http://www.medscape....warticle/738863

AAMC also reports contradictory evidence, but seems to emphasize the positive a little more. http://www.letfreedo.../diabetes_5.htm

With the jury out on cannabis treatment for diabetes, does anyone here have anecdotal evidence? Got diabetes and noticed any effects, positive or negative, from cannabis use?

I don't have diabetes myself but may have a genetic predisposition, so I'm going to go with the CBD lab mice for now and hope cannabis' preventative powers are on my side.

[Sasquatch]

I'm a Type 1 diabetic, and it's the first time I've seen cannabinoid receptors blamed for decline in insulin production.Did the authors actually isolate cannabinoid receptors as the sole cause of insulin inhibition? It's difficult to argue the point with this little to go on but I would have thought that once the insulin producing cells are dead they stay that way.Besides which it's only insulin inhibition that this concerns, if they are correct then the straightforward remedy would simply be take more insulin.
I've never noticed smoking have much effect on my blood glucose levels one way or the other. I lost the bookmark in a system crash but there was an article cited on here showing that CBD could ameliorate the chemical reactions associated with retina damage in diabetics with retinopathy.

Whatever this 'pharmacological blockade' of the receptors is, I would hope it was specific to the pancreas since a general attack on all the receptors in all organs could play havoc, as well as reducing one's ability to get stoned !

[Tuzio]

CBD would trigger CB2 receptors, not CB1, which are triggered by THC. Then again, blocking a CB receptor seems like a very retarded idea to me.

/Tuz

Edit: I'm a type 1 too

This post has been edited by Tuzio: 21 March 2012 - 08:18 PM

[twigs]

from granny storm crows list 2012

CANNABIS AND DIABETES

Cannabidiol Preserves Retinal Neurons and Reduces Vascular Permeability in Experimental Diabetes (abst - 2004)
http://abstracts.iov...ourcetype=HWCIT

The effect of WIN 55,212-2, a cannabinoid agonist, on tactile allodynia in diabetic rats.
(abst – 2004) http://www.ncbi.nlm....pubmed/15519750

Cannabidiol lowers incidence of diabetes in non-obese diabetic mice (full - 2005) http://www.ncbi.nlm....?tool=pmcentrez

Activation of the Peripheral Endocannabinoid System in Human Obesity
(full - 2005) http://www.ncbi.nlm....?tool=pmcentrez

Gpr40 Gene Expression in Human Pancreas and Insulinoma. (abst – 2005)
http://medical-journ...-and-insulinoma

The Ffa Receptor Gpr40 Links Hyperinsulinemia, Hepatic Steatosis, and Impaired Glucose Homeostasis in Mouse. (abst – 2005)
http://medical-journ...stasis-in-mouse

Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes (full - 2006) http://www.ncbi.nlm....72/?tool=pubmed


Regulation, Function, and Dysregulation of Endocannabinoids in Models of Adipose and ß-Pancreatic Cells and in Obesity and Hyperglycemia (full - 2006)
http://jcem.endojour...3eee8eb61349982

Weight Control in Individuals With Diabetes (full - 2006)
http://care.diabetes...ourcetype=HWCIT

Changes in endocannabinoid and palmitoylethanolamide levels in eye tissues of patients with diabetic retinopathy and age-related macular degeneration. (abst – 2006) http://www.ncbi.nlm....pubmed/17011761

Expression of the Gene for a Membrane-bound Fatty Acid Receptor in the Pancreas and Islet Cell Tumours in Humans: Evidence for Gpr40 Expression in
Pancreatic Beta Cells and Implications for Insulin Secretion. (abst – 2006)
http://medical-journ...sulin-secretion

The Cannabinergic System as a Target for Anti-inflammatory Therapies
(abst - 2006) http://www.ingentaco...000013/art00008

Non-Psychoactive Cannabinoid Reduces Incidence Of Diabetes, Study Says
(news - 2006) http://www.norml.org...m?Group_ID=6909

Marijuana Compound May Help Stop Diabetic Retinopathy (news - 2006)
http://www.scienceda...60227184647.htm

Cannabidiol, a marijuana compound, may help stop diabetic retinopathy (news – 2006)
http://www.xagena.it...58dd0b6f17.html

Marijuana Compound Offers Hope In Diabetic Retinopathy Prevention (news – 2006)
http://www.bio-medic...vention-8121-1/

Cannabidiol reduces the development of diabetes in an animal study (news - 2006)
http://www.cannabis-...el.php?id=219#3

Getting Eye On Cannabinoids (news - 2006)
http://www.thehempir...on_cannabinoids

Marijuana compound could prevent eye damage in diabetics (news - 2006)
http://www.thehempir...ge_in_diabetics

Cannabidiol arrests onset of autoimmune diabetes in NOD mice (full - 2007)
http://safeaccess.ca...acology2007.pdf
263

Expression of Cannabinoid CB1 Receptors in Models of Diabetic Neuropathy
(full - 2007)
http://jpet.aspetjou...ourcetype=HWCIT

Cannabidiol attenuates high-induced endothelial cell inflammatory response and barrier disruption (full - 2007) http://www.pubmedcen...&tool=pmcentrez

US Patent Application 20070099987 - Treating or preventing diabetes with cannabidiol
(full – 2007) http://www.patentsto...7/fulltext.html

Role of cannabinoid CB2 receptors in glucose homeostasis in rats (abst – 2007)
http://www.sciencedi...01429990700249X

The synthetic cannabinoid HU-210 attenuates neural damage in diabetic mice and hyperglycemic pheochromocytoma PC12 cells (abst - 2007) http://lib.bioinfo.pl/pmid:17604177

Anticoagulant Effects of a Cannabis Extract in an Obese Rat Model (abst - 2007)
http://marijuana.res...ive/4/4/736.htm

Mediation of Cannabidiol anti-inflammation in the Retina by Equilibrative Nucleoside Transporter and A2A Adenosine Receptor (full - 2008) http://www.ncbi.nlm....?tool=pmcentrez

The Role of Adipocyte Insulin Resistance in the Pathogenesis of Obesity-Related Elevations in Endocannabinoids (full – 2008)
http://diabetes.diab...9e-4650931c5e25

GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity (full - 2008) http://www.ncbi.nlm....?tool=pmcentrez

Endocannabinoid Dysregulation in the Pancreas and Adipose Tissue of Mice Fed With a High-fat Diet (full - 2008) http://www.nature.co...by2007106a.html

Neuroprotective effects of cannabidiol in endotoxin-induced uveitis: critical role of p38 MAPK activation. (full - 2008) http://www.ncbi.nlm....95/?tool=pubmed

Endocannabinoids and the Control of Energy Homeostasis (full – 2008)
http://www.jbc.org/c...96-7fd75bb49403

Mediation of Cannabidiol Anti-inflammation in the Retina by Equilibrative Nucleoside Transporter and A2A Adenosine Receptor (full – 2008) http://www.iovs.org/...49/12/5526.full

Presence of functional cannabinoid receptors in human endocrine pancreas. (abst – 2008)
http://www.ncbi.nlm....pubmed/18092149
264

Cannabidiol As a Putative Novel Therapy for Diabetic Retinopathy: A Postulated Mechanism of Action as an Entry Point for Biomarker-Guided Clinical Development. (full - 2009) http://www.ncbi.nlm....20/?tool=pubmed

Cannabinoids as novel anti-inflammatory drugs. (full - 2009)
http://www.ncbi.nlm....14/?tool=pubmed

Cannabinoid CB2 Receptor Potentiates Obesity-Associated Inflammation, Insulin Resistance and Hepatic Steatosis (full - 2009) http://www.ncbi.nlm....60/?tool=pubmed

The endocanabinnoid system and diabetes - critical analyses of studies conducted with rimonabant (full - 2009) http://www.ncbi.nlm....?tool=pmcentrez

Biological effects of THC and a lipophilic cannabis extract on normal and insulin resistant 3T3-L1 adipocytes (abst - 2009)
http://www.unboundme..._L1_adipocytes_

Anti-inflammatory effect of palmitoylethanolamide on human adipocytes. (abst – 2009)
http://www.ncbi.nlm....pubmed/19131941

Beneficial effects of a Cannabis sativa extract on diabetes induced neuropathy and oxidative stress. (abst - 2009)
http://www.unboundme...idative_stress_

Cannabis plant extracts could potentially form the basic ingredients for a market-leading diabetes drug (news – 2009)
http://www.thefreeli......-a0202701009

Expression and function of cannabinoid receptors in mouse islets. ( full – 2010)
http://www.landesbio...LiISLETS2-5.pdf

Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain (full - 2010)
http://www.ncbi.nlm....?tool=pmcentrez

Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression. (full - 2010) http://www.ncbi.nlm....48/?tool=pubmed

Cannabinoid Receptor 1 Blockade Ameliorates Albuminuria in Experimental Diabetic Nephropathy (full – 2010)
http://diabetes.diab...cc-4aec5dfac384
265

Cannabinoid Receptors are Coupled to Stimulation of Insulin Secretion from Mouse MIN6 β-cells (full – 2010)
http://content.karge...name=320527.pdf

Differential alterations of the concentrations of endocannabinoids and related lipids in the subcutaneous adipose tissue of obese diabetic patients (full - 2010) http://www.lipidworl.../content/9/1/43

Cannabinoid receptor stimulation impairs mitochondrial biogenesis in mouse white adipose tissue, muscle, and liver: the role of eNOS, p38 MAPK, and AMPK pathways.
(full – 2010) http://diabetes.diab...826.long#sec-25

Cannabidiol protects retinal neurons by preserving glutamine synthetase activity in diabetes. (full - 2010) http://www.ncbi.nlm....07/?tool=pubmed

Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy
(full - 2010) http://www.natap.org...s/marijuana.pdf

Rehashing endocannabinoid antagonists: can we selectively target the periphery to safely treat obesity and type 2 diabetes? (full – 2010) http://www.jci.org/a...ew/44099?search[abstract_text]=&search[article_text]=cannabinoid& search[authors_text]=&search[fpage]=&search[title_text]=&search[volume]=

Novel GPR119 agonist AS1535907 contributes to first-phase insulin secretion in rat perfused pancreas and diabetic db/db mice. (abst – 2010) http://www.ncbi.nlm....pubmed/20937249

AS1907417, a novel GPR119 agonist, as an insulinotropic and β-cell preservative agent for the treatment of type 2 diabetes. (abst – 2010) http://www.ncbi.nlm....pubmed/20816753

Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age. (abst – 2010) http://www.springerl...37q1lh40l15161/

GPR119 agonists for the potential treatment of type 2 diabetes and related metabolic disorders. (abst – 2010) http://www.ncbi.nlm....pubmed/21094910

Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation.
(abst – 2010)
http://www.unboundme...i_inflammation_

Pot Compound Mitigates Diabetic Cardiomyopathy (news - 2010)
http://www.norml.org...m?Group_ID=8424
266

Cannabinoids inhibit and may prevent neuropathic pain in diabetes. (news - 2010)
http://medigardens.b...it-and-may.html

Lab Notes: Pot Has Benefits for Diabetic Hearts (news - 2010)
http://www.medpageto.../LabNotes/23853

Cannabinoid receptor 2 signaling does not modulate atherogenesis in mice (full– 2011)
http://www.ncbi.nlm....75/?tool=pubmed

Role for cannabinoid receptors in human proximal tubular hypertrophy. (full– 2011)
http://content.karge...0323997&typ=pdf

Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. (abst – 2011) http://www.unboundme...cardiomyopathy_

Central Endocannabinoid Signaling Regulates Hepatic Glucose Production and Systemic Lipolysis (abst – 2011) http://diabetes.diab...4/1055.abstract

Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic β-Cells (abst – 2011)
http://diabetes.diab...cc-4aec5dfac384

Acute cannabinoid receptor type 1 (CB1R) modulation influences insulin sensitivity by an effect outside the central nervous system in mice. (abst – 2011) http://www.ncbi.nlm....pubmed/21340622

Cannabinoid receptor agonists and antagonists stimulate insulin secretion from isolated human islets of Langerhans. (abst – 2011)
http://www.unboundme..._of_Langerhans_

A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans.
(abst – 2011) http://www.ncbi.nlm....pubmed/21885477

Protective Role of Cannabinoid Receptor Type 2 in a Mouse Model of Diabetic Nephropathy. (abst – 2011) http://www.ncbi.nlm....pubmed/21810593

Cannabinoids and Endocannabinoids in Metabolic Disorders with Focus on Diabetes. (abst – 2011)
http://www.unboundme...us_on_Diabetes_

Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress. (abst – 2011) http://www.ncbi.nlm....pubmed/21238581
267

Win 55,212-2 reduces cardiac ischaemia-reperfusion injury in zucker diabetic fatty rats: role of cb2 receptors and cardiac inos/enos expression. (abst – 2011)
http://www.unboundme...nos_expression_

GPR119 Regulates Murine Glucose Homeostasis Through Incretin Receptor-Dependent and Independent Mechanisms (abst – 2011)
http://endo.endojour...b3-fea533824b24

Cannabidiol Dampens Streptozotocin-Induced Retinal Inflammation by Targeting of Microglial Activation (abst - 2011)
http://abstracts.iov...ourcetype=HWCIT

The cytoprotective effects of oleoylethanolamide in insulin-secreting cells do not require activation of GPR119. (abst – 2011) http://www.ncbi.nlm....pubmed/22029844

The Endocannabinoid System: Plant-Derived Cannabinoids in Diabetes and Diabetic Complications. (abst – 2011) http://www.ncbi.nlm....pubmed/22155112

Takeda moves potential first-in-class diabetes drug into phase III (news – 2011)
http://www.inpharm.c...k-875-phase-iii

This post has been edited by twigs: 21 March 2012 - 08:40 PM

[Nu Jerzey Devil]

I have a friend who is a diabetic and he has problems keeping his sugar levels correct and ends out in hospital, very ill on frequent occasions

He finds it is a mixture of things that cause him to become ill.

Due to smoking cannabis he gets the munchies and he ends out eating lots of sugary and fatty foods, Sweets, Take Aways ect ect

He ends out drinking fizzy juices and cups of tea with sugar in them because he gets very thirsty

Due to him being stoned He forgets to take his insulin or gets to Lazy and doesnt bother with it.

He has only been taking insulin for 2 years and became a diabetic in his Adult life. So he finds it very hard to be a Stoner and a Diabetic as he just wants to sit about and get wasted, eating and drinking what ever he wants and also wanting to forget about having to jag his stomach to get insulin in to him

He gets un well from eating loads of sugary foods and not taking his insulin and we have to take him to hospital

The doctors always tell him that the cannabis is making his kidneys work hard and makes him want to drink more. They say this is what makes him so ill so quickly

I think I would also find it hard adjusting to life as a Diabetic

[Merrytricks]

It's all too complex for my comprehension, even on my least-ill days, and today I'm slowly reading aloud to myself while following the text with my index finger... but there's not much available to try to comprehend, lacking a paid subscription.

This link doesn't give any specifics on how the study was conducted.
http://stke.sciencem...ourcetype=HWCIT

Remind me, next life, study biochemistry and don't get too ill to read. I'd love to be able to read all those links, and understand them, twigs.

[Sasquatch]

Twigs if I could award you the week's rep points ration I would. Cheers mate.

NJD, your mate needs to keep up to testing his blood glucose before he does anything and drink diet fizz or use sweeteners.

Quote

So he finds it very hard to be a Stoner and a Diabetic as he just wants to sit about and get wasted, eating and drinking what ever he wants and also wanting to forget about having to jag his stomach to get insulin in to him

It's the emotional burden it puts on you that does the most damage,at first it seems like a constant pain in the ass you can't see why you have to endure. I hope he manages to get used to it. Know how he feels, sugary foods seem like a drug in themselves.

Quote

The doctors always tell him that the cannabis is making his kidneys work hard and makes him want to drink more.

That's a new one to me, I always thought the kidneys worked harder trying to expel excess sugar. High blood sugar leads to high blood pressure, which is bad for the kidneys. Sugar is acid and having high average sugar for years can corrode things like the fine tubules in the kidneys.

[Tuzio]

Nu Jerzey Devil, on 21 March 2012 - 10:25 PM, said:

He ends out drinking fizzy juices and cups of tea with sugar in them because he gets very thirsty

Drinking sugary drinks will make him even more thirsty, plus anything with straight glucose in them should be avoided unless it's accompanied with less bioavailable food (like protein, fats, or more complex carbs)

Nu Jerzey Devil, on 21 March 2012 - 10:25 PM, said:

Due to him being stoned He forgets to take his insulin or gets to Lazy and doesnt bother with it.

I'm probably quick in my judgement, but that's insane. While his cells will starve, the sugar will sit in his blood, making it thick and acidic. The body will then have to resort to fats, whose byproduct is ketones, which will make the blood even more acidic. Nerves, liver, kidneys will suffer and he will get dehydrated as the body will have to use whatever water it can find to get rid of the excess sugar right away - You'll recognise this as he will hit the loo every 10 minutes.

Nu Jerzey Devil, on 21 March 2012 - 10:25 PM, said:

He has only been taking insulin for 2 years and became a diabetic in his Adult life. So he finds it very hard to be a Stoner and a Diabetic as he just wants to sit about and get wasted, eating and drinking what ever he wants and also wanting to forget about having to jag his stomach to get insulin in to him

Doctors can be pretty superficial when they train people who have been just diagnosed with diabetes. One very useful thing that your friend can do is train himself to assess the amount of carbs he's eating, this way: putting all the stuff he's going to eat for a meal together, "guestimating" how many units of insulin that corresponds to, then actually calculating it (by looking at the pack or looking up resources over the internet). In a few months this training will allow him to look at *anything* and just know right on the spot how much he needs to inject for it. Another very useful thing is learning how to recognise the symptoms of both excessive and insufficient blood sugar - when I'm too high I get irritable and my stomach gets upset, when I'm too low my pressure drops, I feel anxious and I crave sweets (up until the point I tremble and start proper freaking out)

Nu Jerzey Devil, on 21 March 2012 - 10:25 PM, said:

He gets un well from eating loads of sugary foods and not taking his insulin and we have to take him to hospital

refuse to make him smoke until he's got his food carb counted - you don't want to police him of course, but he should not make you responsible for his wellbeing if he "can't be bothered". It's a very irresponsible attitude.

Nu Jerzey Devil, on 21 March 2012 - 10:25 PM, said:

The doctors always tell him that the cannabis is making his kidneys work hard and makes him want to drink more. They say this is what makes him so ill so quickly

After 5 and 1/2 years with the disease I can confidently tell you that the doctors and diabetic nurses contradict one another and say a lot of shit that doesn't make much sense. Diabetes is not an exact science. He shouldn't avoid sugar or carbohydrates, it's literally impossible (also, he would probably die) - but he needs to inject the right amount of insulin for *any carbohydrates he eats*, or he risks getting gastroparesis (a horrible neurodegenerative complication that makes your stomach stop digesting, and they'll fit him a feeding tube for him to eat every single time), blindness (sudden, not a bit at a time, the retina detatches and you're fucked), kidney failure (they'll regularly have to clean up your blood through a machine, it's called dialysis and it's extremely unpleasant), amputation of the feet, and more. He absolutely needs to get it sorted.

Nu Jerzey Devil, on 21 March 2012 - 10:25 PM, said:

I think I would also find it hard adjusting to life as a Diabetic

Probably, after two years, you wouldn't. The trouble for a diabetic is not the injections, it's mainly psychological - people not understanding your situation or looking at him weird when he injects, having to jump through hoops in order to obtain medication, or even just the thought of no longer being independent from "the system". Give your mate all the support you can, but he absolutely needs to pull his head out of his arse before he ruins his life and face his problem. Diabetes won't go away just because he throws temper tantrums. Suggest to him to get on a diabetic forum, that helps really really much.

Best of luck to your friend, dude.

/Tuz

[Sasquatch]

Perhaps also worth pointing out that having a high blood glucose level robs you of energy and can make you feel lazy, and can turn you into a foul tempered cnut.
Point it out to him anyway, he does need to get a grip.

[DaSmokster]

I could see the kidney thing being right.

I allways get thirsty when smkoing and drink way more stooned.

[bogcotton]

Here is the full article for all who are interested: http://goo.gl/XjPBl

(I hope nobody has already posted this, if so, sorry!).

Edit #1: Whoops! Screwed that one up nicely. Having a look for the right one now.

Edit #2: Here is the actual full article: http://goo.gl/PvyuT

What a way to do a first post.

This post has been edited by bogcotton: 22 March 2012 - 07:52 PM

[wildbill]

I get low blood sugar & often need to eat every 3hrs ish. When I smoke that changes to 20mins later. I don't usually smoke unless munchies are available.

So this article could explain why.

[Tuzio]

DaSmokster, on 22 March 2012 - 03:31 PM, said:

I could see the kidney thing being right.

I allways get thirsty when smkoing and drink way more stooned.

that's because it lowers your pressure. Being thirsty is no evidence of kidney damage. Eating sugar, fat or salt makes you thirsty, but I have never heard of that being bad for the kidneys (if you do it in moderation, of course).

[Sasquatch]

Quote

I get low blood sugar & often need to eat every 3hrs ish. When I smoke that changes to 20mins later. I don't usually smoke unless munchies are available.

So this article could explain why.

I think that's just you being well controlled and having low blood sugar a lot. It's pretty well the same thing as non-diabetics getting the munchies, which is probably something to do with smoking triggering insulin release or something and could be taken as evidence for smoking being good for diabetics.

[Gom Jibbar]

b.wild, on 22 March 2012 - 08:02 PM, said:

I get low blood sugar & often need to eat every 3hrs ish. When I smoke that changes to 20mins later. I don't usually smoke unless munchies are available.

So this article could explain why.

I'm the same. But I find that all I need is a *little* something sweet immediately after smoking and a pint of water. I avoid smoking on an empty stomach. Sativas seem to affect blood sugar more than Indicas.