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Hi,
does anyone have any helpful info regarding this?
many thanks..
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Motor Neurone Disease Or Als
Any info much appreciated...
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#1
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Posted 11 April 2011 - 07:50 PM
#2
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Posted 11 April 2011 - 07:55 PM
pez, on 11 April 2011 - 07:50 PM, said:
Hi,
does anyone have any helpful info regarding this?
many thanks..
does anyone have any helpful info regarding this?
many thanks..
some linkys here..
https://sites.google...teral-sclerosis
https://sites.google...ons-brain-cells
https://sites.google...neuroprotectant
"Wake up in the morning and it's hard to live...."
#3
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Posted 11 April 2011 - 08:01 PM
That's fantastic, thankyou very much for your succinct reply PH. Kind regards
#4
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Posted 11 April 2011 - 08:07 PM
Cannabinol delays symptom onset in SOD1 (G93A) transgenic mice without affecting survival.
Weydt P, Hong S, Witting A, Möller T, Stella N, Kliot M.
Department of Neurology, University of Washington, Seattle, WA 98195, USA. weydt@u.washington.edu
Abstract
Therapeutic options for amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disorder, remain limited. Emerging evidence from clinical studies and transgenic mouse models of ALS suggests that cannabinoids, the bioactive ingredients of marijuana (Cannabis sativa) might have some therapeutic benefit in this disease. However, Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the predominant cannabinoid in marijuana, induces mind-altering effects and is partially addictive, compromising its clinical usefulness. We therefore tested whether cannabinol (CBN), a non-psychotropic cannabinoid, influences disease progression and survival in the SOD1 (G93A) mouse model of ALS. CBN was delivered via subcutaneously implanted osmotic mini-pumps (5 mg/kg/day) over a period of up to 12 weeks. We found that this treatment significantly delays disease onset by more than two weeks while survival was not affected. Further research is necessary to determine whether non-psychotropic cannabinoids might be useful in ameliorating symptoms in ALS.
sauce
e2+
PH is on it..
Weydt P, Hong S, Witting A, Möller T, Stella N, Kliot M.
Department of Neurology, University of Washington, Seattle, WA 98195, USA. weydt@u.washington.edu
Abstract
Therapeutic options for amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disorder, remain limited. Emerging evidence from clinical studies and transgenic mouse models of ALS suggests that cannabinoids, the bioactive ingredients of marijuana (Cannabis sativa) might have some therapeutic benefit in this disease. However, Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the predominant cannabinoid in marijuana, induces mind-altering effects and is partially addictive, compromising its clinical usefulness. We therefore tested whether cannabinol (CBN), a non-psychotropic cannabinoid, influences disease progression and survival in the SOD1 (G93A) mouse model of ALS. CBN was delivered via subcutaneously implanted osmotic mini-pumps (5 mg/kg/day) over a period of up to 12 weeks. We found that this treatment significantly delays disease onset by more than two weeks while survival was not affected. Further research is necessary to determine whether non-psychotropic cannabinoids might be useful in ameliorating symptoms in ALS.
sauce
e2+
PH is on it..
This post has been edited by twigs: 11 April 2011 - 08:10 PM
link - Cannabis shown to reduce invasiveness of cancer - National Cancer Institute
The lethal dose ratio (LD-50) for cannabis is estimated to be around 1:20,000 to 1:40,000 which means you have to consume 20,000 to 40,000 times as much cannabis as is contained in one cannabis joint to induce death. This means you would have to consume something like 1,500 lbs in 15 minutes to induce a lethal response. There are no known fatalities from the substance and it is considered non- toxic...
...''First they ignore you; then they mock you; then they punish you; then you win."
Mahatma Ghandi
The lethal dose ratio (LD-50) for cannabis is estimated to be around 1:20,000 to 1:40,000 which means you have to consume 20,000 to 40,000 times as much cannabis as is contained in one cannabis joint to induce death. This means you would have to consume something like 1,500 lbs in 15 minutes to induce a lethal response. There are no known fatalities from the substance and it is considered non- toxic...
...''First they ignore you; then they mock you; then they punish you; then you win."
Mahatma Ghandi
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