Motor Neurone Disease Or Als Any info much appreciated...
Posted 11 April 2011 - 07:55 PM
does anyone have any helpful info regarding this?
some linkys here..
Posted 11 April 2011 - 08:07 PM
Weydt P, Hong S, Witting A, Möller T, Stella N, Kliot M.
Department of Neurology, University of Washington, Seattle, WA 98195, USA. firstname.lastname@example.org
Therapeutic options for amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disorder, remain limited. Emerging evidence from clinical studies and transgenic mouse models of ALS suggests that cannabinoids, the bioactive ingredients of marijuana (Cannabis sativa) might have some therapeutic benefit in this disease. However, Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the predominant cannabinoid in marijuana, induces mind-altering effects and is partially addictive, compromising its clinical usefulness. We therefore tested whether cannabinol (CBN), a non-psychotropic cannabinoid, influences disease progression and survival in the SOD1 (G93A) mouse model of ALS. CBN was delivered via subcutaneously implanted osmotic mini-pumps (5 mg/kg/day) over a period of up to 12 weeks. We found that this treatment significantly delays disease onset by more than two weeks while survival was not affected. Further research is necessary to determine whether non-psychotropic cannabinoids might be useful in ameliorating symptoms in ALS.
PH is on it..
This post has been edited by twigs: 11 April 2011 - 08:10 PM
The lethal dose ratio (LD-50) for cannabis is estimated to be around 1:20,000 to 1:40,000 which means you have to consume 20,000 to 40,000 times as much cannabis as is contained in one cannabis joint to induce death. This means you would have to consume something like 1,500 lbs in 15 minutes to induce a lethal response. There are no known fatalities from the substance and it is considered non- toxic...
...''First they ignore you; then they mock you; then they punish you; then you win."