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Six volunteers are seriously ill in hospital after a medical trial at a private clinic in France. One of the six is described as "brain dead" while the other five are critically ill, according to the newspaper Ouest France. The trial is related to a cannabis-based painkiller, led by a European laboratory, the newspaper said. "A serious accident took place during a therapeutic trial near Rennes," Health Minister Marisol Touraine said. She added that the trial had been halted and all volunteers taking part recalled. The minister said the six patients had been in good health until taking the oral medication. A formal investigation has been opened in Paris.