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  1. Interesting read, well cited circa 2016. Hope its useful to someone looking for referenceable research. Link to article - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4791148/ Integrating cannabis into clinical cancer care D.I. Abrams, MD* Author information Copyright and License information Disclaimer This article has been cited by other articles in PMC. Go to: Abstract Cannabis species have been used as medicine for thousands of years; only since the 1940s has the plant not been widely available for medical use. However, an increasing number of jurisdictions are making it possible for patients to obtain the botanical for medicinal use. For the cancer patient, cannabis has a number of potential benefits, especially in the management of symptoms. Cannabis is useful in combatting anorexia, chemotherapy-induced nausea and vomiting, pain, insomnia, and depression. Cannabis might be less potent than other available antiemetics, but for some patients, it is the only agent that works, and it is the only antiemetic that also increases appetite. Inhaled cannabis is more effective than placebo in ameliorating peripheral neuropathy in a number of conditions, and it could prove useful in chemotherapy-induced neuropathy. A pharmacokinetic interaction study of vaporized cannabis in patients with chronic pain on stable doses of sustained-release opioids demonstrated no clinically significant change in plasma opiates, while suggesting the possibility of synergistic analgesia. Aside from symptom management, an increasing body of in vitro and animal-model studies supports a possible direct anticancer effect of cannabinoids by way of a number of different mechanisms involving apoptosis, angiogenesis, and inhibition of metastasis. Despite an absence of clinical trials, abundant anecdotal reports that describe patients having remarkable responses to cannabis as an anticancer agent, especially when taken as a high-potency orally ingested concentrate, are circulating. Human studies should be conducted to address critical questions related to the foregoing effects. Keywords: Cannabis, cannabinoids, symptom management, nausea, anorexia, pain Go to: INTRODUCTION Much attention has been paid to the unearthing of the 2500-year-old mummy known as the “Siberian Ice Maiden.” Discovered in 1993, her subterranean burial chamber included a pouch of cannabis among other archeologic findings1. Magnetic resonance imaging revealed that the princess had a primary tumour in the right breast, with axial adenopathy and metastatic disease. It is hypothesized that the cannabis was used to manage her pain and perhaps other symptoms, or even possibly as a treatment for her malignant disease. Widely used as medicine during the ensuing millennia, cannabis disappeared from the pharmaceutical armamentarium in the 1940s as its prohibition took hold. Today, we are in the midst of what appears to be something of a medicinal cannabis renaissance, with patients across the globe gaining increased access to this potent botanical medicine. In a 2014 WebMD poll, 82% of oncologists indicated their belief that patients should have access to cannabis, ranking highest among medical subspecialists in their support2. Regrettably, most oncologists trained during the era of cannabis prohibition and have no knowledge of how to use the plant as medicine. In these days of targeted therapies and nanotechnology, the modern oncologist might feel somewhat ill at ease recommending a herbal intervention, notwithstanding the number of potent cytotoxic chemotherapeutic agents derived from plants. An even more vexing concern to the oncologist is the lack of data on which to base treatment recommendations. Given the nature of the drugs that they prescribe, oncologists are used to seeing strong evidence of a favourable risk–benefit ratio before recommending a therapeutic intervention. Usually, oncology drugs have proceeded through preclinical studies, followed by the traditional phase i, ii, and iii analyses, before we feel comfortable adding them to our toolbox. Such data about the clinical effectiveness of medicinal cannabis are all but lacking. In the United States, cannabis is classified as a Schedule I agent with a high potential for abuse and no accepted medical use. The study of cannabis requires a special Schedule I license from the U.S. Drug Enforcement Administration. In addition, the only legal source of cannabis for clinical trials is the National Institute on Drug Abuse, which has a congressional mandate to study substances of abuse only as substances of abuse. Although investigators can obtain National Institute on Drug Abuse cannabis to conduct effectiveness clinical trials, funding must come from another source. Hence, carefully controlled clinical trials of cannabis as a therapeutic agent—the sorts of trials that would satisfy a data-driven oncologist—are quite rare. In 1986, Δ9-tetrahydrocannabinol (thc), the most psychoactive cannabinoid in the plant, was approved as a licensed drug, dronabinol (Marinol: AbbVie, North Chicago, IL, U.S.A.), for the treatment of chemotherapy-induced nausea and vomiting. Hence, oncologists probably have the longest record of using a cannabis-based medicine. In 1992, the dronabinol indication was expanded to include treatment of the anorexia associated with aids wasting syndrome. In 2006, nabilone (Cesamet: Meda Pharmaceuticals, Somerset, NJ, U.S.A.) another synthetic thc that had long been available in Europe and elsewhere became available in the United States as well. The foregoing drugs are thc alone and do not include any of the other potentially therapeutic cannabinoids, terpenoids, or flavonoids that are present in the whole plant3. Cannabidiol (cbd), in particular, is another of the phytocannabinoids that has been generating significant interest for its potential therapeutic effects4. Nabiximols (Sativex: GW Pharmaceuticals, Salisbury, U.K.) is a whole-plant extract of cannabis that has been processed to have a thc:cbd ratio of 1:1. Originally approved in Europe for the treatment of central pain associated with multiple sclerosis, this sublingual preparation has also been studied in a number of cancer-related conditions5–8. Because most of the information derived from clinical trials on cannabinoids in cancer is derived from studies of those licensed pharmaceuticals, the present review discusses findings from studies of those agents as well as from studies of cannabis itself. Go to: CANNABIS FOR PAIN To date, two types of cannabinoid receptors (seven-transmembrane domain G protein–coupled receptors) have been identified in humans and other animal species9. The cb1 receptor, initially identified in the brain, is found in high concentrations in areas involved in the processing of noxious stimuli. The cb2 receptor is predominantly located in cells of the immune system and likely has a role in the control of inflammation and cell proliferation. The cb receptors are not present to react with the phytocannabinoids from cannabis alone. They exist because, on demand, humans produce endogenous cannabinoids—“endocannabinoids”—that react with the receptors, effecting changes in intracellular signalling. It has been suggested that the entire function of the system of cannabinoid receptors and endocannabinoids might be to assist in modulation of the response to pain. With that in mind, it is not surprising that an increasing body of knowledge is being developed about the effects on pain of cannabinoid medicines. A recently published systematic review10 considered 28 studies involving a total of 2454 participants and preparations including inhaled cannabis, dronabinol, nabilone, and nabiximols, among others. Twelve of the studies investigated neuropathic pain, and three looked at patients with cancer pain. The studies generally showed improvement in pain measures, with an overall odds ratio of 1.41 (95% confidence interval: 0.99 to 2.00) for improvement in pain with the use of cannabinoids compared with placebo. An earlier systematic review of eighteen randomized controlled trials of cannabinoids in 766 participants with chronic non-cancer pain found that fifteen of the studies reported a significant analgesic effect for the cannabinoids compared with placebo, and a number of the studies also noted improvements in sleep11. Another review that included six of those eighteen studies in patients with cancer-related pain also favoured cannabinoids12. Neuropathic pain is certainly problematic in cancer patients13. A systematic review of six randomized, double-blind, placebo-controlled trials of cannabinoids (five specifically addressing neuropathic pain) found evidence for the use of low-dose medical cannabis in refractory neuropathic pain in conjunction with traditional analgesics14. Another analysis reviewed five trials of inhaled cannabis in patients with hiv-related peripheral neuropathy and again found a positive effect for cannabis compared with placebo15. A recent small study16 showed a dose–response effect for vaporized cannabis in the relief of pain from diabetic peripheral neuropathy, a huge clinical problem estimated to affect 238 million people worldwide. With all of those impressive data suggesting that cannabinoids could be effective in peripheral neuropathy, where are the studies in patients with chemotherapy-induced peripheral neuropathy? Preclinical studies in rodent models have suggested that cannabinoids might actually be able to prevent peripheral neuropathy. Activation of the cb1 and cb2 receptors suppresses the development of vincristine-induced peripheral neuropathy in rats17. In mice receiving daily cisplatin, administration of anandamide (an endocannabinoid) together with an inhibitor of the fatty-acid amide hydrolase that metabolizes anandamide attenuated chemotherapy-induced peripheral neuropathy18. Cannabidiol pretreatment stops paclitaxel-induced neuropathy in mice19. To date, the only human study of a cannabis-based medicine in chemotherapy-induced peripheral neuropathy is a crossover placebo-controlled trial of nabiximols20. Overall, reported pain scores were not different with nabiximols and with placebo. However, on a 0–10 scale, 5 responders reported a greater than 2-point decline in neuropathic pain. That observation suggests that 5 patients have to be treated with the sublingual preparation for 1 to experience clinical benefit (an acceptable number-needed-to-treat for a neuropathic condition), suggesting that further investigation of cannabis medicines in chemotherapy-induced peripheral neuropathy is warranted. Even more exciting would be a study demonstrating the potential for cannabis to actually lower the risk for neuropathy or to prevent it from developing in the first place, as the animal models suggest. In animal models, cannabinoids and opioids have been demonstrated to have synergistic analgesic effects21. Analgesic effects of cannabinoids are not blocked by opioid antagonists, suggesting that the two types of agents work through different receptors and pathways. An early study found that thc was ineffective as an analgesic on its own, but that it slightly increased the effect of morphine on 2 of 3 measures22. A randomized controlled trial of dronabinol in patients on opioids for chronic pain found that, compared with placebo, dronabinol reduced pain (p < 0.01) and increased patient satisfaction (p < 0.05)23. A randomized controlled trial of nabiximols in 359 cancer patients with poorly controlled pain despite a stable opioid regimen found that the sublingual preparation (4, 10, or 16 sprays daily for 5 weeks) reduced both pain and sleep disruption24. A pharmacokinetic interaction study of vaporized cannabis in 21 patients with chronic—mostly non-cancer—pain taking sustained-release morphine or sustained-release oxycodone showed no significant effect on plasma levels of the opiates, but a suggestion of enhanced analgesia25. However, that small study was not powered for a pain endpoint, suggesting that a larger follow-on trial is warranted26. Clinically, I have observed that many cancer patients benefit from adding cannabis to their pain regimen. Although the effect on chemotherapy-induced peripheral neuropathy has not been glaringly obvious, other sorts of cancer-related pain appear to respond. Patients who have been put on high doses of opiates at the end of life by their well-meaning oncologist or palliative care team frequently feel totally unable to communicate with their loved ones in their precious remaining time because of altered cognition. Many have successfully weaned themselves down or off their opiate dose by adding cannabis to their regimen. Although it would seem that thc-dominant strains of cannabis would be most likely to have analgesic effects, patients often report significant pain reduction from strains that are predominantly cbd-rich. Although cbd does not actually bind to the cb1 receptor, it does block the fatty-acid binding protein that transports the endocannabinoid intracellularly to be hydrolyzed by the fatty-acid amide hydrolase, hence allowing the endogenous cannabinoid complexed with the receptors to persist27. Go to: CANNABIS FOR NAUSEA As an oncologist practicing medicine in San Francisco since the early 1980s, I have often said that I need a clinical trial to demonstrate that cannabis is an effective antiemetic about as much as I need a placebo-controlled trial to demonstrate that penicillin is an antibiotic! It would appear that, if the single most active constituent of the plant is licensed and approved for treatment of chemotherapy-induced nausea, that the parent botanical should also work. Being aware that the plural of anecdote is not evidence, I would like to share an e-mail message from a 42-year-old gentleman with metastatic colon cancer requesting a renewal of his medical cannabis authorization: Although I did not use it until my last 5 sessions of chemo (me getting over the stigma of its use), it did what no other drug could do, completely solve the severe nausea I had. It allowed me to play with my children, attend their sports and school functions, and just function very normally in day to day activities. I cannot thank you enough for giving me that option! I am currently on a chemo vacation after a clean scan, and the only time I use medical marijuana now is when I have trouble sleeping. I would like to continue to use it for that purpose instead of relying on pharmaceutical options like zolpidem etc. That message is representative of what many patients have recounted to me over the past 30-plus years of oncology practice in a locale in which patients have never had difficulty accessing cannabis. However, data from controlled clinical trials of cannabis are less impressive. Only three trials have looked at cannabis in the treatment of chemotherapy-induced nausea and vomiting, and in two of them, cannabis was made available only after dronabinol had already failed. The first trial noted a significant benefit for cannabis compared with placebo in patients receiving high-dose methotrexate28. A later study by the same investigators made cannabis available to patients receiving cyclophosphamide or doxorubicin after dronabinol failure, and no beneficial effect was noted29. The third study investigating cannabis was a randomized crossover trial in 20 patients who received dronabinol and cannabis30. Overall, 5 of the patients reported a positive antiemetic response. Of the entire cohort, 4 patients preferred smoked cannabis, 7 preferred dronabinol, and 9 had no preference. A recent phase ii investigation in 16 patients of nabiximols, the sublingually delivered whole-plant extract, found that 4.8 sprays daily was more effective than placebo in conjunction with standard antiemetics31. Data from studies investigating the synthetically available versions of Δ9-thc have provided more convincing evidence. A quantitative systematic review32 that included 30 randomized comparisons of oral nabilone, oral dronabinol, or the intramuscular levonantradol preparation (no longer available) with placebo in 1366 patients receiving chemotherapy found that, as antiemetics, cannabinoids were more effective than prochlorperazine, metoclopramide, chlorpromazine, thiethylperazine, haloperidol, domperidone, or alizapride (risk ratio: 1.38; 95% confidence interval: 1.18 to 1.51). For complete control of nausea, the number needed to treat was 6, and it was 8 for complete control of vomiting. In crossover trials, the patients preferred cannabinoids for future chemotherapy cycles. A later systematic review33 of thirty randomized controlled trials involving 1138 patients also found that cannabinoids were more effective than placebo or conventional antiemetics in reducing chemotherapy-induced nausea and vomiting, and that patients preferred the cannabinoids. Adverse effects were noted to be more intense and to occur more frequently in patients using cannabinoids. A more recent systematic review10 of twenty-eight randomized controlled trials (twenty-three using nabilone or dronabinol) involving 1772 participants reported an overall benefit for cannabis. A Cochrane review34 analyzed twenty-three randomized controlled trials of cannabinoids compared with placebo or with other antiemetic drugs. Patients were more likely to report a complete absence of nausea and vomiting with cannabis than with placebo, and there was little discernable difference between the effectiveness of cannabinoids and of prochlorperazine, metoclopramide, domperidone, and chlorpromazine. Notably, however, none of the trials involved the agents now most widely used—the serotonin 5-HT3 antagonists. The National Comprehensive Cancer Network guidelines cautiously mention cannabinoids as a breakthrough treatment for chemotherapy-induced nausea and vomiting not responsive to other antiemetics35. Go to: CANNABIS FOR APPETITE STIMULATION Although cannabis is the only antiemetic that is also orexigenic, no clinical trials investigating the plant as a treatment for cancer-related anorexia–cachexia syndrome have been conducted to date. A randomized placebo-controlled clinical trial evaluating a cannabis extract and dronabinol in 243 patients with cancer-related anorexia–cachexia syndrome found that neither preparation was superior to placebo with respect to affecting appetite or quality of life36. A large study of 469 advanced cancer patients randomized participants to receive the progestational agent megestrol acetate or dronabinol, or both37. Compared with participants in the dronabinol group, those in the megestrol arm experienced a significantly greater increase in both weight and appetite, and combining dronabinol with megestrol offered no additional benefit compared with megestrol alone. One smaller study of dronabinol in cancer patients demonstrated enhanced chemosensory perception in the treatment group compared with the placebo group38. In the dronabinol recipients, food tasted better, and appetite and caloric intake increased. Similarly variable and largely unimpressive results for dronabinol with respect to appetite and weight in hiv-associated wasting have also been reported39. Go to: CANNABIS FOR CANCER One of the lay accounts concerning the tomb of the Siberian Ice Maiden closes with these lines: Modern-day scientists have increasingly been turning their attention to cannabis due to its potential to inhibit or destroy cancer cells, and at the very least, manage the pain and symptoms that come with the illness. But then, ancient people seem to have known that already.40 That sort of a leap—assuming that because the Ice Maiden was buried with cannabis and had cancer, that she was using it to treat her cancer—is about as valid as the claims being made on the Internet today that highly concentrated cannabis oils can cure cancer. It might be possible, but there is, as yet, no solid evidence to support that belief. One of the more distressing situations that oncologists increasingly face is trying to counsel the patient who has a curable diagnosis, but who seeks to forego conventional cancer treatment in favour of depending on cannabis oil to eradicate their malignancy because of the large number of online testimonials from people claiming such results. Given my long practice in San Francisco, I can assume that a large proportion of my patients have used cannabis during their journey. If cannabis cured cancer, I would have a lot more survivors in my practice today. Granted, inhaled cannabis cannot deliver the concentration of active ingredients that a heavily concentrated thc or cbd oil can, but there is as yet no convincing demonstration that the in vitro or animal model findings translate into the clinical arena. One of the earliest studies suggesting that cannabinoids might have anticancer activity came from the U.S. National Cancer Institute in a paper published in 197541. Investigators reported that Δ9-thc, Δ8-thc, and cbd inhibited the growth of Lewis lung adenocarcinoma cells in vitro and in mice. For unclear reasons, that line of research was not pursued further at the National Institutes of Health in the United States, but was subsequently picked up by investigators in Spain and Italy, who have made enormous contributions to the field. If cannabinoids are postulated to have a potential anticancer effect working through the cb1 receptor, it would follow that the brain—where the cb1 receptor is the most densely populated seven-transmembrane domain G protein–coupled receptor—would be a good place to start the investigation. And, in fact, numerous studies in vitro and in animal models have suggested that cannabinoids can inhibit gliomas42. Other tumour cell lines are also inhibited by cannabinoids in vitro, and cannabinoid administration to nude mice curbs the growth of various tumour xenografts representing multiple solid and hematologic malignancies, including adenocarcinomas of the lung, breast, colon, and pancreas, and also myeloma, lymphoma, and melanoma43,44. A discussion of the mechanism of action of cannabinoids as anticancer agents is beyond the scope of the present article, but has been reviewed elsewhere45–48. Cannabinoids appear to induce apoptosis, probably through interaction with the cb1 receptor. Cannabinoid administration in mouse models has been observed to reduce the expression of vascular endothelial growth factor and its receptors, leading to inhibition of angiogenesis. Cannabinoids also decrease the activity of matrix metalloproteinase 2, leading to decreased tumour-cell invasiveness and decreased potential for metastasis. In addition, cannabinoids have anti-inflammatory and antioxidant properties that are also desirable in combatting cancer. In vitro studies have demonstrated that, combined with gemcitabine, cannabinoids further reduce the viability of pancreatic cancer cells49. In mice, adding thc to temozolomide (used widely in treatment of aggressive brain tumours), reinstated glioma suppression in tumours that had become resistant to chemotherapy50. The addition of cbd enhanced the antitumour activity even when lower doses of thc were used. Similarly, a combination of thc and cbd was found to enhance the antitumour effects of radiation in a murine glioma model, suggesting that cannabinoids might be synergistic with radiation therapy as well as with chemotherapy51. But again, mice and rats are not people, and what is observed in vitro does not necessarily translate into clinical medicine. The preclinical evidence that cannabinoids might have direct anticancer activity is provocative as well, but more research is warranted. Hence, the oncologist advising patients on the use of cannabinoids during conventional cancer treatment should be aware of the preclinical findings and should not reflexively advise patients to avoid cannabis altogether. Currently, we can be confident that cannabis could have utility in symptom management for patients living with and beyond cancer52–54. Compared with most of the therapeutic agents that oncologists use in their practice, the side-effect profile of cannabis as medicine is acceptable, and the adverse effects are well described54,55. To be able to suggest a single agent that could hold benefit in the treatment of nausea, anorexia, pain, insomnia, and anxiety instead of writing prescriptions for 5 or 6 medications that might interact with each other or with cancer-directed therapies seems advantageous. And although botanical–pharmaceutical interactions for other drugs metabolized by certain cytochrome P450 isoforms is a theoretical possibility, no significant perturbations in the plasma concentrations of prescription medications have been seen to date when cannabis is co-administered. The only published study investigating medicinal cannabis with chemotherapeutic agents found no effect on the plasma pharmacokinetics of irinotecan or docetaxel when cannabis was administered as a herbal tea, although that delivery system is neither particularly popular nor likely potent56. The pharmacokinetics of ingested compared with inhaled cannabis would support an inhaled route of administration if patients desire more control over the onset, depth, and duration of the effect. Go to: CONCLUSIONS The august New England Journal of Medicine published a perspective piece describing Marilyn, a 68-year-old woman with metastatic breast cancer seeking medical cannabis from her physician57. Interestingly, the pro and con sides of the argument were both presented by mental health practitioners and not by medical oncologists. In a follow-up blog poll, the authors reported finding it surprising that 76% of the 1446 physicians responding from around the world were in favour of medicinal cannabis, even though many came from jurisdictions in which it is totally illegal58. The authors of a later WebMD survey of 1566 physicians in the United States reported that 82% of oncologists and hematologists were in favour of patients having access to medical cannabis—representing the strongest approval among all medical subspecialties2. To summarize, cannabis and cannabinoids are useful in managing symptoms related to cancer and its treatment. Exciting preclinical evidence suggests that cannabinoids are not only effective in the treatment but also in the prevention of chemotherapy-induced peripheral neuropathy. Cannabinoids could be synergistic with opioids in the relief of pain. The safety profile of cannabis is acceptable, with side effects that are generally tolerable and short-lived. Preclinical data suggest that cannabinoids could have direct antitumour activity, possibly most impressive in central nervous system malignancies. Clinical data about the effects of cannabis concentrates on cancer are as yet unavailable. Oncologists could find cannabis and cannabinoids to be effective tools in their care of patients living with and beyond cancer. Go to: CONFLICT OF INTEREST DISCLOSURES I have read and understood Current Oncology’s policy on disclosing conflicts of interest, and I declare the following interests: I have received fees as an advisory board member for ABcann Medicinals, MMJ PhytoTech, Tikun Olam, and Zynerba Pharmaceuticals. Go to: REFERENCES 1. Mosbergen D. New York, NY: The Huffington Post; 2014. Now We Know What Killed the Ancient “Ice Princess”, and Why She Had That Marijuana [Web article]. [Available at: http://www.huffingtonpost.com/2014/10/16/siberian-ice-princess-cancer-cannabis_n_5993052.html; cited 19 December 2015]. [Google Scholar] 2. 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  2. I find myself in the position where I'm contemplating a claim against my local hospital. I wondered if there were folk on here who made a claim and wouldn't mind sharing their experience. I was diagnosed with mouth cancer 6 years ago and underwent the chop, poison, burn method. That's surgery followed by chemo, followed by radiotherapy. We got rid of the cancer, which is the main thing. I was told before the op that I would have virtually full function after a period of recuperation. I had a pretty radical op called a pectoral flap which involved taking a strip of attached flesh from my chest, opening up my face and patching the hole where the cancer was. Then sew me all together. I was in for six weeks. We had a few complications and I was readmitted a couple of times. Both times I'd collapsed at home and needed emergency admission. I swear I nearly died both times -I'd never felt so ill! I'm a pretty tough character, I mean tough as resilient rather than hard. I keep a positive outlook on life and I fight to stay happy. However I've been struggling recently. Despite what the doctors said I've never been able eat or drink since the op and still have a PEG tube to my stomach. I've had no solid food for 6 years! I've regained the four stone I lost but the nutrition doesn't give me enough energy to function fully. I'm permanently knackered and suffer with permanent reflux and acid. I feel nauseous every morning and throw up most mornings. My voice hasn't recovered although my friends understand me, Alexa hasn't a clue what I'm on about. On top of that people treat me like I'm stupid or taking the piss! I have pretty bad scarring on the chin and neck and my chest looks like a shark attack!! You get the idea! Now Friday morning I get a call from the Head of Surgery at the hospital. There been an investigation into the head and neck cancer surgery dept and they came up sadly lacking. (I took part in the investigation and met with representatives from the Royal College of Surgeons) Then surgeries were suspended and people walked or were pushed. They identified a dozen patients who had been harmed by their treatment and was sorry to say I was one of them. I always knew things weren't right and my concerns were brushed aside for years. I should be able to talk ok, eat, drink and smile - I can't do any of them. I met with the new surgeon and the head of surgery face to face this week and they were full of grovelling apology. When asked what were they going to do to put it right, they said there was nothing they could do and we were past a point of no return! He's going to take a screw out of jaw and give me a new feed pipe. Whoopee! Anyway, then he hand me the number for the Head of the Legal Dept to discuss compensation. I rang the guy today and he's willing to talk as long as I haven't engaged a lawyer yet, which I haven't. I'm meeting him end of next week so I'm trying to get my head round my situation. It's turned my head upside down!! I'd just like to hear of other peoples experiences. Hopefully it'll help me think this through. I live alone with my little dog and I don't get folks to talk to that often.
  3. https://www.thegrowthop.com/cannabis-health/u-k-man-with-terminal-brain-cancer-denied-medical-cannabis-prescription Gannon’s partner says that despite the fact that the U.K. has recently started allowing medical cannabis to be prescribed on the NHS, his doctors at Royal Stoke University Hospital are refusing to do so A 29-year-old British man with terminal brain cancer has been denied a medical cannabis prescription from the hospital where he has been receiving cancer treatment. After two surgeries and 10 rounds of radiotherapy, George Gannon was told by his medical team that there was little else they could do to treat the brain tumour that had doubled in size since his initial diagnosis. The bad news was confirmed on December 21 with the results of an MRI performed shortly after Gannon started immunotherapy–a treatment that “helps to strengthen or restore the immune system’s ability to fight cancer,” per the Canadian Cancer Society. Gannon is now taking steroids in order to reduce brain swelling, but as a result is unable to persist with immunotherapy as it is incompatible with the drugs. With his physicians recommending palliative care, his only hope of getting well enough to continue is seeking alternative treatments such as cannabis and CBD oil. But Gannon’s partner says that despite the fact that the U.K. has recently started allowing medical cannabis to be prescribed on the NHS, his doctors at Royal Stoke University Hospital are refusing to do so. Natalie Hobbs expressed her frustration at hospital staff and what she says is their lack of co-operation. “We’ve approached his GP, oncologist and nurses at the hospital and they are dismissive,” she told iNews. “His GP just said we don’t understand what cannabis does yet and that was that.” Gannon’s CBD oil costs £600 per month, or approximately CAD$1025. Hobbs has started a GoFundMe to help pay for his treatment, but decries the lack of assistance she says they have received from the medical community. “We are giving him CBD oil off the shelf and because it’s not regulated as medicine we don’t really know for sure what strength or type of cannabinoids we are giving him. If we had a prescription we would do. So it’s just guess work, which isn’t good enough when it’s about life or death of a 29-year-old.”
  4. I've had so much admiration for everyone who has been growing to care for their loved ones and friends... I didn't think I'd be looking for advice, but today, a couple of weeks after feeling a slight ache in her right side, my lovely mother in law has been diagnosed with metastatic breast cancer. She has tumours in her right breast, liver, spinal column and lymph nodes. We are waiting for a prognosis, which we do not hold out much hope for, and plan of treatment. My wife and I are in a state - worse because we can't be with her or my father in law at present because they are in Germany and we are in the UK - even if we were there, she has chosen to isolate herself and refuse visitors. Can't blame her, god knows what is going through her mind and she has to come to terms in her own way. Also, I am not in a position to help by growing, so I am really looking for any helpful information from anyone who has any knowledge or experience of German medical marijuana, which I know has been leagalised, though I do not know how best to advise on accessing treatments. Any other useful links to information would be greatly appreciated. I have read a diary on here on stage 4 breast cancer, which ended on what seemed to be a positive note, in 2015 - are there any other resources you know of on the boards, please? Thanks for any advice/suggestions or pointers. Good health to you all.
  5. https://www.timesofisrael.com/cancer-patient-sues-health-ministry-over-trimmed-marijuana-prescriptions/ A cancer patient who takes medical cannabis is petitioning the courts over a drastic cut to his prescribed dosage, part of a new reform from the Health Ministry that has angered patients and advocates and forced hundreds of medical cannabis users to cut their usage. Yehudah Haber, 58, submitted a petition to the Jerusalem District Administrative Court court on Thursday over his medical cannabis prescription, which was slashed from 200 grams to 90 grams per month earlier this year, against the advice of four of his doctors. Haber was diagnosed with Stage II oligodendrogliomas, a type of brain tumor, when he was 39, one of three cancerous growths he has dealt with since his army service. Haber was a Shayetet 13 naval commando who trained in the polluted water of the Kishon River, and, like many other members of his unit, was diagnosed with cancer linked to his service. Get The Times of Israel's Daily Edition by email and never miss our top storiesFREE SIGN UP “In the US, they say, ‘Join the Navy and see the world,’ but here, it’s ‘Join the Navy and see the hospital,’” Haber said. Medical marijuana smoking supplies at a store adjacent to the ‘Tikun Olam’ store in Tel Aviv, on April 10, 2016. Tikun Olam Ltd. is the largest supplier of medical Cannabis in Israel, operating under license from the Health Ministry since 2007. (Hadas Parush/Flash90) Originally Haber’s doctors gave him a diagnosis of less than a year to live. That was 19 years ago. But after beating the odds, three years ago his brain tumor became anaplastic, a much more malignant cancer stage that also caused epileptic episodes. Taking approximately 200 grams of medical cannabis per month, in both flower and oil form, stopped the epileptic seizures and halted the growth of the anaplastic brain tumor, said Haber. The Health Ministry first notified Haber that it was cutting his dosage in June, without consulting his doctors, who strongly opposed the move. For the past three months, Haber has only been able to obtain 90 grams per month. He said the epileptic seizures have returned and the tumor has started growing again. In November, the tumor was classified as Stage III-IV, and Haber was given about a year to live. Attorney Miriam Brainin is representing Haber. Last month, Brainin won two similar cases, one in which an 82-year-old woman with terminal breast cancer saw her cannabis prescription reduced from 250 grams to 90 grams per month, and another where a cancer survivor’s cannabis prescription was lowered from 140 grams to 90 grams per month. In both cases, the Jerusalem District Court ordered the Health Ministry’s Medical Cannabis Unit to give the patients the original amount prescribed by their doctors. Brainin says she believes Haber will have the same result, though the hearing could take up to a month. Haber is one of hundreds of people in a similar situation whose cannabis prescriptions have been reduced, said Dana Bar-On, the CEO of the Medical Cannabis Association. Bar-On herself has had her prescription slashed twice. In 2015, Bar-On, who takes medical cannabis to deal with symptoms of a neuromuscular disease, had her prescription cut from 180 grams per month to 50 grams. Within four months, she had lost 20 kilograms and was forced to start using a wheelchair and oxygen, said Bar-On. Yehudah Haber, 58, has used medical cannabis oil to halt the growth of his tumor and stop epileptic seizures that accompanied the tumor. (Courtesy) A spokesperson for the Health Ministry said the reductions are due to an increase in the demand for medical cannabis — to ensure that there is enough for all of the patients who require it. The Medical Cannabis Unit received 57,781 requests for new cannabis licenses or changes in 2018, compared with 14,910 requests in 2013, an increase of 387 percent. “In order to protect the public and patients, the Ministry approves the use of cannabis in dosages and indications [using the correct drug to treat a certain disease] when enough information has accumulated to reasonably conclude that it is helpful and safe,” the spokesperson said. The Ministry refused to comment on reductions in dosage or the process for changing an existing patient’s dosage in the middle of treatment without consulting doctors. But Bar-On called the Ministry’s reasoning “ridiculous and offensive,” noting that if the Health Ministry was so concerned with the amount of cannabis for Israeli patients, the government should not have approved the export of medical cannabis. After more than a year of delay, the Knesset approved the export of medical cannabis on December 25, just before dissolving ahead of elections, which will take place on April 9. According to the law, police will be responsible for enforcing export regulations, one of the requests of Public Security Minister Gilad Erdan, who has previously opposed the idea of Israel exporting medical marijuana. A number of logistics regarding marijuana exports still need to be hammered out with cabinet approval, so it could be a year or two before the first medical cannabis is exported from Ben Gurion Airport. Bar-On noted that multiple times during the hearings about medical marijuana exports, the Medical Cannabis Unit testified that there was sufficient cannabis in Israel for all Israeli patients who required it. A man is restrained by security guards after drinking cannabis oil during a hearing of the Knesset Health Committee on legalizing medical marijuana. (Screen capture: Knesset Channel) The reduction is part of the Health Ministry’s cannabis reform, which, among other things, will require patients to start paying for medical marijuana based on the size of their dosage, said Bar-On. A patient using 200 grams per month could be required to pay as much as NIS 2,300 ($620) monthly, she said. Currently, all patients with a license for medical marijuana pay a flat monthly fee of NIS 370, regardless of how much marijuana they obtain through their prescription. The Health Ministry spokesperson declined to comment on future increases in the cost of the medication. “The state knows that as the prescriptions are higher, they might have to subsidize more [of the cannabis],” said Bar-On. “By reducing the prescription amounts from the get-go, they won’t have to pay as much to subsidize.” A worker tends to cannabis plants at a growing facility for the Tikun Olam company near the northern city of Safed, August 31, 2010. (Abir Sultan/Flash 90) There are about 38,000 patients who have medical marijuana prescriptions in Israel, up from 10,000 in 2012. Currently, cannabis is approved to treat cancer, chronic neuropathic pain, post-traumatic stress disorder, colitis, Parkinson’s, epilepsy, HIV/AIDS, Crohn’s disease, multiple sclerosis, Tourette’s syndrome, and terminal illness. Soon, cannabis is expected to be approved for autism and fibromyalgia. “If they said the same thing for chemotherapy, that suddenly they’re going to start reducing the chemotherapy for all cancer patients, would it sound logical?” asked Bar-On. “Or what if they said the same thing about insulin for diabetics, that they are cutting in half the amount of insulin diabetics are getting. There would be an immediate investigation. “This is no different. We’re talking about the sickest people in the country, for whom conventional medicine doesn’t work.”
  6. Hey Everyone, I have seen quite a few posts regarding oil and methodology so I thought I would start my own topic because as you will soon see it is vast and in depth. I can also pop a link in my sig this way so I can point people here when I see someone who needs help. OK so I have been making oil for my Dad for a few months now. It's been a bit of trial and error up to now but I think I have finally nailed it. IMO my method is safer healthier stealthier and better for the environment than Rick Simpson's method. I use isopropyl alcohol as my solvent, lesson number 1 is not all ISO is created equal. Make sure you get hold of 99% pure ISO otherwise you're going to have a bad time! Readily available from that great river online bookshop. Buy bulk it's cheaper. Then buy a rice cooker the current one I'm using cost £15 from the big green supermarket. Lesson number 2 don't buy expensive rice cookers you are going to ruin and break them and cheap ones work prefectly fine. I just went for their cheapest own brand one which has a glass lid. (more on that later) Now where my method is slightly different from Rick's I use a copper condenser coil to reclaim my ISO and eliminate the highly volatile and toxic fumes ISO is nasty nasty stuff. I got the idea after watching a documentary about Popcorn Sutton a famous moonshiner in the States. I bought some 8mm copper pipe (which came very loosely coiled) from a DIY store to make my coil. You want space (approx 1cm gaps) between the coils to allow the water to cool and condense the ISO vapours. About 8 coils should be enough more is better. This copper coil was made by threading some string through the copper tube and then wrapping the copper around a pringles tube. Then removing the string. The string was used to prevent the tube from kinking. In hind sight sand is probably better as the string can be difficult to remove. So fill the copper pipe entirely with sand plug both ends with gaffa tape and boom! If it does kink you can usually fix it with pliers but take your time and wind very slowly and you should be good. Ensure you leave a nice straight bit at one end (approx 8cm long) this will become the spout your, nice, safe(ish) liquid ISO will drain from. Also leave plenty of extra uncoiled tube at the other end of the coil. This will be used to attach the coil to the rice cooker. I then used a 5l water bottle (the cheapest one that big blue supermarket has) as a water chamber for the coil but any sealed plastic vessel wide enough should do. Empty the water out the screw the lid back on then very carefully drill an 8mm hole in one side about 1-2" from the bottom then cut the top of the bottle off ensuring that your copper coil fits mostly inside the bottle. Gently feed the coil into the bottle ensuring the spout lines up with the hole this is quite fiddly and you may need a hack saw to trim the spout down a touch so that it fits. This might take a few attempts to get right. Now feed the spout section through the 8mm hole. Now secure the top of the coil to the top of the bottle using wire. Drill a couple of very small holes in the top of the bottle to anchor the wire through and twist the wire round the coil a few times to ensure it is properly secured. Now seal the spout and hole at the bottom I used epoxy resin but bathroom sealant would have been easier but I didn't have any. The top half of the coil gets very hot and will melt plastic or burn anything it comes into contact with. So make sure the top of the coil isn't in direct contact with the bottle. Also be mindful of that when working around it. I've had a couple of minor burns (nothing that left a mark) when I've not been paying attention. In the lid of the rice cooker is a small vent hole to allow steam to escape. There is a rubber grommet that you need to pull out but it's not very hard to do a pinch and a yank is all you need. I then used a rotary engraving kit with a pink grinding stone to widen the hole to just over 8mm allowing the copper tube to fit with ease. This means when the lid is on the vapor is forced up the tube where it begins to cool and condense back into a liquid as it makes its way down the coil it gets cooler and cooler until at the end it is pure liquid ISO again. This can then be poured back into a container and reused. When widening the hole you need to ensure the copper tube has a tiny bit of wiggle room. If it doesn't you risk shattering the glass lid. The tube should slide easily into the hole (oi oi! ) so don't try to force it. Or you might need to buy another rice cooker (that was lesson 3! ) To make the seal airtight simply use a small amount of electrical tape about 1cm away from the end of the tube. Then you can shove the tube into the hole and the tape creates a seal. You will need to replace this from time to time but it works well enough. You should end up with a contraption that looks something like this: Now you are ready to start making your oil. Here is a list of things you will need: -Measuring beakers I use a couple of 250ml pyrex ones and a couple of 500ml pyrex ones -Unbleached coffee filters -Funnels (I just cut the tops off a few bottles) -A glass mixing bowl -A spare Kilner Jar -A soft silicon cake spatula -A stainless steel sieve -Syringes -An electric candle warmer -Rubber gloves (optional) -Kitchen roll -An oven mit -A tipex pen/ permanent marker -Last but not least some high grade, preferably organic, cannabis! Stage 1 Take your dried cannabis and chop it up with scissors in the glass mixing bowl. Once chopped into relatively small bits transfer into a kilner jar. Now add your ISO just enough to cover the plant material. shake like a mad man /woman for 1-2 mins. open the kilner jar and shove the scissors in there and start chopping this will remove any residue on the scissors and also breaks up the plant a bit more. Close the jar and shake for another 1-2 mins. Now put your sieve over the glass bowl and empty the contents of the jar into the sieve. Use the spatula to press any excess liquid out of the sieve. you should now have a golden / green liquid in the bowl and all plant material in the sieve. Transfer the plant material back into the jar. Don't forget to wipe the spatula with kitchen roll once finished. Stage 2 Grab your funnels and coffee filters set the filters inside the funnels and pop both into the 500ml pyrex measuring beakers the more the merrier I find 3 is optimal when processing approx 2oz of plant material. Pour the mixture from the bowl evenly between the filters. Leave these to filter. Stage 3 Go back to your jar of plant material and fill with fresh ISO once more shake vigorously for 3-4 mins essentially repeating stage 1 pour the mixture back through the sieve etc etc Stage 4 The beakers should now be filled with filtered solution carefully fold the top of the coffee filters and give them a good squeeze to ensure as much as possible is in the beakers. Now pour the beakers into the rice cooker. Now repeat stage 2 with the second wash. Once the second wash has finished filtering I add this to the rice cooker also. I find for 2 oz of plant material I need approx 1 - 1.5 liters of ISO (500-750 ml for each wash) this is about perfect for the capacity of the rice cooker. Stage 5 Pop the lid on the rice cooker and attach the coil to the lid. Fill the water chamber with you guessed it... water! I like to top it off with a couple of handfuls of ice. Monitor the setup and wait for the liquid to start heating up. you will notice the ice around the top of the coil start to melt make sure you have a suitable container ready under the spout to catch the condensed ISO I use 2 250ml Pyrex beakers for this and swap them around. When one is full it is replaced with an empty one and the full one is emptied back into the ISO container. I find at peak full steam a 250 ml container will fill in about 5 mins so make sure you keep an eye on things and check back regularly you could also use a bigger vessel! I find I manage to reclaim approx 75% of my ISO this way the majority of the loss is soaked into the plant material and you always loss a small amount as vapor and there is always some in the copper tube at the end. Note: Now the first time you run this setup attaching the coil to the lid is a really fiddly part. You will require some patience to get it right. You will need to spend some time gently bending and adjusting the copper tube so that it fits the lid and the lid fits the rice cooker correctly if there is any play in the lid when you press it down you will have a leak through which vapor will escape. You will know this is happening because everything will smell very strongly of alcohol. If this starts to happen mid way through processing the oil don't panic. Take your oven mit and see if you can make an adjustment to fix the leak. you can also try adjusting the angle of the rice cooker. If it continues to leak you will want to power everything down and move it to a well ventilated area. Don't mess about with ISO it's toxic and you do not want to breathe those fumes in. From here you have 2 options see if you can make adjustments to fix the leak, or finish this stage by boiling off the remainder of the alcohol in a well ventilated area as per Rick's method. But if you are patient and persistent you can get the setup working. Once you have found an arrangement that works, I recommend marking the copper tube and rice cooker lid with a tipex pen or marker so you know how that lines up. Then mark the lid and the rice cooker so you know how that lines up. this will ensure the angles are always correct after you find the sweet spot. Stage 6 Eventually the rice cooker will flip from "Cook" to "Warm" this is usually around the time the oil has reached a pretty concentrated state you will see there will be hardly anything left and what is left should be black and thick and bubbling. Now here is the part where you need to act pretty quick. Whilst the oil is hot it is relatively easy to handle and will run like a normal liquid as soon as it starts to cool it turns to the consistency of Marmite / Honey it is incredibly stickyand difficult to manipulate. So the key is to act whilst it is still warm. So before it cools you want to prep one of your 250ml beakers and your candle warmer. Set the beaker on the candle warmer and switch it on. Then grab your oven mit and your spatula. (make sure you didn't forget to clean the spatula if you did clean it now) put the oven mit on your weak hand, with the oven mit pull the copper tube out of the lid the tube will be very hot so the mit is very much required. Now remove the lid then remove the hot bowl from the rice cooker (again using the mit.) Now with the spatula in your strong hand tip the contents of the bowl into the beaker on the candle warmer use the spatula to scrape the residue into the beaker also. (Don't panic about leaving a small amount in the bowl and on the spatula just clean this off with a small amount of ISO and add that ISO to your next run.) The aim here is to do the best job you can you will never get it all out. Stage 7 Now that your oil is in the candle warmer the end is in sight but don't rush this stage. There is a small amount of ISO in your oil still and the candle warmer is here to fix that. Watch the oil closely and you will notice tiny bubbles on the surface this is the last of the ISO evaporating this stage can take a while depending on how much ISO is left in the oil. You will know it is ready when the surface of the oil is perfectly still without any bubbles it will look like black glass and will smell strongly of cannabis. Because it is still warm the oil will still be quite runny now grab a syringe and tilt the beaker so the oil collects in a corner. Pop the tip of the syringe so that it is just in the oil gently draw up the plunger to about half way. Now carefully knock any drops of oil off the tip. Then hold the syringe with the tip pointing directly up pull the plunger down a bit more to clear the oil from the nozzle and now very carefully and very slowly push the plunger up until there is no air left in the syringe. Repeat this process until the syringe is full. Rinse and repeat until you can't get any more oil from the beaker. I now add ISO to the beaker to get the remaining residue dissolved and I add this ISO to the ISO I used to clean the rice cooker and spatula this is then stored in a jar ready for the next run. Conclusion Following this method I average approx 7g of finished oil from 2oz of plant material meaning you will need approx 16-17oz of premium bud to get 60g of oil. I know this method doesn't yield more but there are many benefits to doing things this way. But what I will say is this was a method I discovered for myself and I have quite a few runs under my belt now so I think this is maximum efficiency. but there is always room for improvement. Now if you have made it this far a salute you! that's a whole heap of reading. This is just my method that I have worked out through much trial and error. There are some shortcuts you can skip the whole condenser coil its an added bonus that i believe everyone should use but it is agro until you get it right. But it does work! no fumes no risk of explosion which means a reduced risk of losing a batch IMO very worth it from this perspective alone. There are other benefits such as economy etc. But yeah if you have the cash you can invest in a proper copper still you will have to faff monitoring temps to ensure you are not burning off precious cannabinoids. It's late and I've spent a long time writing this today but if it helps someone it was all worthwhile. Happy to answer any question and give any advice. Also I'm open to any suggestions on how I can improve my technique I will continue to add to and update this thread with discoveries and further tips I will get round to another post on dosage and how to measure dosage etc Until then keep it green NezA
  7. Paul Stamets mentions that his Mum had inoperable cancer and he treated it with mushroom derived medicine. He talks quickly, and he's talking to scientists (not laymen) so he is getting technical at times, but try and understand what he's talking about. I've watched it several times and it gets easier.
  8. im not 100% sure about ian r crane but he does some good stuff about fracking . part1 https://www.youtube.com/watch?v=3eatiNg6tg8 part2 https://www.youtube.com/watch?v=QMpIPgr2l8I part3 https://www.youtube.com/watch?v=3s7ldY_3bw8
  9. Cannabis works! Ive seen it with my own eyes! I posted on here a while back asking for some advice on treating my mates mum who had a very rare cancer of the Petronium original thread is here: http://www.uk420.com/boards/index.php?showtopic=337326 we have been making her lots of oil and turning it into a sublingual tincture by diluting it very slightly with olive oil. Her family blown away at how the oil has helped her, turning her from a really sick person into someone moving towards health. Almost straight away after taking the oil her appetite came back after essentially not eating for 2 weeks after diagnosis, she started to be able to move better and walk more even go visit friends. As things went forward and her tolerance went up we just kept making the dilution of oil stronger and tried to get as much in her as possible. She was necking liquid morphine when we started treatment, a few weeks after treatment was started she had completely stopped the morphine and a few weeks after that she had also managed to stop taking(completely under her own steam) a load of other prescription drugs she had been on long term. they are planning a rather invasive surgery and did a load of tests in prep for that, which is why she just got these tests back and the results were that the cancer markers they were testing for were down from over 1500 to just over 50! the doctors are completely dumbfounded, hehehehe shes on a super healthy diet now with the odd treat and we are continuing with the oil, shes by no means out the woods but this is a really positive indication that we are doing the right thing. If someone you know is really sick with cancer you have to start treatment, it really does work, they can be happy and healthy with this plant. thanks to everyone who helped with advice. I will keep everyone updated as things move forward.
  10. Many of you know of Jeff Ditchfield and his work in the field of cannabis medicines. Well now you have a chance to help find the truth about cannabis and cancer. We fail the sick if we just play about with anecdotal evidence ~ the real need is for hard scientific and empirical evidence. Which costs. Lots. Which is where you come into the equation: Cancer patients need your help. They need your money. NOW! Form an orderly queue, and donate here. Thankyou.
  11. My first grow in an English cellar so not ideal conditions. This is a grow of medical cannabis for oil for my son - a philosopher and musician who enjoys the side effects - but more importantly, maybe the only real hope we have for the cancer in his brain. And I've found these in the grow. Can anyone tell me what they are and how to get rid of them safely without damaging the flowers? Hardly any room to manoeuvre down there so hoping an organic spray that's ok to use with the lights on that I can get in the UK? I'd really appreciate any advice.
  12. Hi everyone, here's my background. I turned 43 this week (argh!) In 2013 my mum got a clot in her leg and investigations led to the discovery of a large cyst on her left ovary. For months leading up to this she'd been going to her GP and saying something was wrong, only to be fobbed off with antibiotics. She's 74 and through the menopause yet she was getting cramps. She never told me this or I'd have gone straight online and investigated, then insisted she go private or change her GP. Anyway she finally had a scan and was told her ovary was the size of a grapefruit, but they told her that it wasn't cancerous (I wondered how the hell they could know this without a biopsy). They operated and removed her ovary and omentum - yet they left her uterus and remaining ovary intact - in a 74 year old woman? They biopsied the ovary and called her back in, sat her down and said they'd found Stage 1 cancer inside it - after initially telling her it was benign. Then they told her they wanted to put her on mild chemo and open her up again for a full hysterectomy. Naturally she burst into tears as she thought she was cancer free. So Christmas 2013 they opened her up again and took everything out, she had the mild chemo and was given the all clear. 4 months prior to all this kicking off, my dad was diagnosed with non-hodgkins lymphoma, but it seemed to be a "mild" version of it (if there is such a thing) as he had no tumours, just a very low blood count - they put him on chemo (neither him or mum lost hair or had any vomiting during their chemo), he needed no surgery and after a few months of this they tested him and told him all traces were gone and he's in the clear. Anyways, while all this was going on I hit the books and the internet to read about cannabis oil as I'd already heard about RSO and was following his Facebook page - I was determined to start growing weed so I could get some oil for the both of them, the problem is my mum is the typical Daily Mail reader who is terrified of the entire world, very VERY negative, and thinks that Cannabis is a gateway drug to heroin and certain death. I seriously doubt she'd EVER sit down and inform herself about the potential benefits of RSO, and consider taking some of the oil to help herself. She's now on steroids for an all-over muscle ache problem, and each phone call is a run down of pills, tests, and appointments she's having - she's become obsessed with every little ache Dad meanwhile, is carrying on as normal and not worrying about stuff or what he went through - a much better mindset than mum. Dad used to smoke weed when he was in the merchant navy and I think he'd be a bit more open to using the oil, but I'd have to give him some under my mum's radar. As it is he's now in the all clear but perhaps as he gets older it may return. When he was first diagnosed they told him it was "not curable but treatable" and that it would get worse as he got older - yet they have since given him the all clear and he's doing fine.....confusing?? Nearly a year to the day of my mum having her first scan and finding the ovarian cyst, I started having weird crampy symptoms between periods, and I had an ultrasound and lo and behold - on my left ovary, I also had a cyst - a much smaller one as I'd caught it early - and within 2 months of this scan I'd had keyhole surgery and the ovary was removed, and all was well. I have a big-assed fibroid too, apparently. I'm now showing similar symptoms again and I'm terrified my other ovary is going kaput. I'm not keen on going on hormones if I lose my other ovary, but I doubt I'll have a choice. Due to various issues going on last year which mainly included my old garage being demolished and having to wait for a new one, my plans to grow got delayed and the urgency went down a bit when both parents were medically given the all OK. So it's probably too late to grow anything that may help out whatever's going on with my remaining ovary, but I'm still going to do the RSO grow just for general health benefits as I get older, and so I will have a supply in case my dad gets badly again. My mum has no idea that I've had surgery as I don't want her phoning me and pouring negativity down the phone at me about it, plus worrying herself to bits. Dad doesn't know either. If my other ovary is on it's way out and I have to have more surgery then I will probably have to tell her but for now I'm just keeping an eye on my symptoms, hoping it's a peri-menopause thing, and will go to the docs if the symptoms continue. Any advice on good strains to grow will be great, I've settled on Medical Seeds White Widow at the moment. I don't sleep much, average 4.5/5 hours a night, it's been like this for years (I've got a busy mind!) so maybe something that I can take at night that will get me a good nighs kip would be for the best. Would be interested to hear any other non-hodgkins or ovary-related stories. I just wish my mum was a bit more open-minded about cannabis and at least educate herself on it before making a decision - as it is she just rubbishes things and refuses to listen to anyone
  13. Hello crew, I was advised by a friend to come on here to seek some advice and support. My very good friends mum, a wonderful and special lady has just been diagnosed with the rare and supposedly peritoneal cancer which has metastasised to her lung. At first the doctors just sent her home as they said there was nothing they could do, I believe now that she is actually going to start some chemo. It has obviously been a devastating blow to receive this news but luckily she has a beautiful supportive family and big group of friends round her. I have been expressing to her and the family the real importance of her getting good amounts of cannabinoids into her system asap and they of coarse are keen to start this process. The problem is it seems finding the right quality of medicine, It looks like over the next few weeks I can get some reasonably good cannabis to make into RSO for her and she has already been given some butter made by another friend but I suspect what that as made with and also the cannabis I will be able to score will be very low CBD and very high THC, maybe this isn't so bad with her condition? or does she really need high CBD to have a chance at kicking this cancers ass? I am hoping for what she has the THC rich medicine will work. At this point they have told her she has anywhere from a week to 6 months to live, but everyone is taking that guess with a pinch of salt. I really want to try and help her as I know much more than her or her family the importance role this plant can play in balancing and healing the body. I also believe it gives us a a really positive state of being to try and cure her and not just give up. I know there is a lot of knowledge on this forum and that you guys are the best people to ask so please let any thoughts or advice flow free, If you need any particular information regarding her illness I can find anything out. Peace and blessings to you all, EC
  14. HP sauce http://www.uea.ac.uk/mac/comm/media/press/2014/July/cancer-cannabis New research my ass, just look at how the assholes want to create a synthetic patentable version and bleed the public like leaches, make millions, normal, still quite disgusting.
  15. Hya folks, Very happy to have been directed to this site by my hubby. What an amazing amount of good stuff happening here, Danzig, and the folks helping you achive these remissions; you rock. 2013 has been a total challenge for us. Hubby was diagnosed with stage 4 lung cancer in January and told it was incurable, he was given a targeted therapy, a pill a day, which has held his tumours steady, but wont reduce them and wont work for long. He has already beaten the odds as he was told to expect months at best. I was diagnosed with stage 2 breast cancer in October and since then have had my tumours removed. (I have been advised to take chemo for 6 months, Radiotherapy for 5 weeks and Tamoxifen for up to 10 years - I am not going for these options) Where do we go from here... well, we have already changed our diets massively by juicing, alkalising and oxegenating our bodies at every turn. We have researched thoughout the year and have realised that a life time love of weed has a deeper, much deeper healing aspect, in RSO. We managed to get hold of enough bud to make 10 grams of oil and have been both taking a maintanance dose, this is about to run out. We have made plans with gardening pals to grow more and we ourselves are doing the same. This will take several months to come to fruition. The difficulty is always going to be getting enough of what we need. No one we know can manage the quantities and we can only grow so much oursleves. One of my questions for the community here is: Is it better to hold out for weed we know is CBD heavy and grown with more love than chemicals, or should we just bite the bullet and buy the 32 oz we need for the first 2 treatments, never mind it's journey to our door? I am feeling quite panicked about how to proceed short term. I'm supposed to begin Radiotherapy in February. (I have ditched the chemo and Tamoxifen, and hope to avoid the radiotherpay too). Scared about waiting several months to begin treatments as hubbys medicine could fail any time, and I want and need to be fit and well to help him. Any advice very welcome. We are in the Scottish central belt and are fully committed to saving our own lives, rather than being in the hands of the Oncologists. We are both in our 40's and are musicians. All the best. XX
  16. So it seems one can get private CA _ 124 tests done, for anyone that doesnt know what that is, this is the test for tumour markers in the blood, ie testing for the level of tumour activity in the body. I thought this might be useful for any of the oil warriors on here who wanting to supplement the sporadic and nonsensical testing efforts of the NHS. http://privatebloodtests.co.uk/CA-125-blood-test
  17. Hiya folks, Just to quickly set the scene: I have stage 2 breast cancer, diagnosed in October 2013, treated with surgery. Since then I have been in and out of hospital with post surgical complications. The Oncologists are recommending 6 months chemo, 5 weeks radiotherpay and 5 to 10 years Tamoxifen. I dont want any of these treatments. My hubby has stage 4 lung cancer, diagnosed January 2013. Treated with Tarceva (targeted therapy). We are working towards treating ourselves with RSO. This is in hand and we expect to have each done a 60 gram treatment by early autumn. In the meantime we are both using tiny amounts of RSO daily to maintain some tolerance and well being. I spoke to my surgeon 2 weeks ago about our plans to use RSO and I asked for a PET CT scan to give us a baseline to work with regarding RSO treatment success or not. However, it looks as though the only way I can get a PET CT scan is to go private (£850). My surgeon then spoke to his boss, who is the head of the Breast Unit in Edinburgh, Prof Mike Dixon, he has now asked to see me to discuss the RSO treatment. Unfortunatly this appointment is not until 12th March. Hubby has a CT scan and an Oncology appointment tomorrow (21/02/14). Fingers crossed he is still static. Hubby is hoping to discuss the RSO and it's possible contra indications with Tarceva. Unfortunatley (or maybe it will turn out to be fortunate) he is not seeing his usual Oncologist who he has had over a years worth of meetings with. She is away on maternity leave and so he is seeing the head of his department, who we have not met before, Prof Price. So, unexpectadly, we are now both seeing the Professors, the heads of different Oncology departments but who work in the same Centre of Excellence. I am hoping they may be encouraged to talk to each other. We will keep the thread updated as and when we see Oncologists AND when RSO is discussed. I guess the point being that, throughout the UK, OncoloIgy Depts will be gettig more and more people talking about RSO and so I am hoping this thread will help encourge others to speak out. I'm also hoping other folks in the same boat may add their stories here. xx
  18. Morning everyone ! I'm due to have another batch of RSO done for my wife, she has advanced bowel cancer. She's been taking the first batch I had done, but can't get out of diamorphine, which actually had to be increased, she's constantly in pain. Want to get her to have more than a rice grain sized dose per day, but being a good wife she's stubborn as a mule ... Anyways, I need more RSO and will do some in the next few days. My problem is that I do have to make it indoors... know this is no good but have nowhere else, and as we live in a flat ground floor, just by the entrance door, I need to be very discreet (if there is any way possible). We have no family in UK and no friends with garden that we could go to. Will be making the oil over night, about 2am, hoping most of my neighbours will be sleeping then. Need suggestions of methods that could fit my purpose (making the RSO indoors with a minimum of attention from people around). Is it possible? Tried youtube, but mostly videos show outdoors or detached houses. I live in a bloc of flats. The road is pretty quiet specially at night, but still. Help much appreciated!! I have a gas stove, so will be using a rice cooker, or anything else suggested. Cheers.
  19. Hi, my Mums had a rough few months, got diagnosed with a rare type of cancer 'ocular melanoma' - the tumer was very aggresive so they removed her eye but (as is common with this type of cancer) it's spread to her liver, she's going in for a re-section/surgery in a couple of weeks, this type of cancer is not responsive to chemo/radiation etc. and -according to the doctors- after surgery will be back in time. The threads here have been a great help and I've shown her the rick-simpson vids and she wants to give it a go when she recovers from the surgery. I'm looking at two strains - Juanita La Lagrimosa and Skunk Haze- as they are high in cbd which (from what I've read) I think is best for fighting cancer? I want to be as efficient as possible, can anyone give some advice on which strain would be preferable? I'll be growing under 1 600 watt bulb / hydroponic in pebbles, I'm hoping I'll get the 16 ounces dry needed for the full course, but I'm not sure how these strains yeild? Just looking for any advice on this and anything else anyone can think of? thanks for reading
  20. I'm currently taking Tarceva as a treatment for stage 4 lung cancer, and am growing to make RSO as the treatment will not kill my cancer cells, only stop them spreading. Even then, it will only work for so long, and then my cancer is predicted to spread rapidly. So making RSO and will start a 60g treatment as soon as poss. What I would like to find out, is, should I take the oil alongside the Tarceva, as it's working to control my cancer, or stop taking the Tarceva while I'm taking the oil...? Any help, info or advice greatly appreciated. Will be seeing my oncologist in February, but she is not open minded, and doesn't know about RSO. THANKS PALS.... J45....
  21. Just adding this out of interest. Full article here: http://tokesignals.com/parents-thca-tincture-works-just-as-well-as-cbd-for-pediatric-seizures-heres-how-to-make-it/ There Is An Effective, Non-CBD, Non-Psychoactive Way To Control Seizures With Cannabis. Most of us have heard, in the past few months, about the wave of “medical marijuana refugees” descending upon cannabis-friendly destinations like Colorado. Many of these refugees are families who have children suffering from Dravet syndrome and other severe forms of epilepsy and pediatric seizures, and ever since CNN correspondent Dr. Sanjay Gupta’s documentary, “Weed,” more and more of these parents are willing for their kids to try cannabidiol (CBD) oil. Demand for the particular high-CBD strain, Charlotte’s Web, has gone particularly crazy since Dr. Gupta’s show aired, because it was the one mentioned by name. What many panicked parents don’t realize, upon first entering the initially bewildering world of medical cannabis, is that there are a number of other high-CBD strains as well, some with reported numbers higher than those of Charlotte’s Web. Several state Legislatures, particularly in more conservative states such as Alabama, are also considering “CBD-only” legislation which would legalize CBD oil but leave THC illegal. This is particularly unfortunate for a number of reasons. Two of the major ones are (1) research has shown the cannabinoids, including THC and CBD, work most effectively in combination with each other, through syngergistic effects; and (2) the passage of “CBD-only” legislation serves to increase and emphasize the “scariness” and “otherness” of THC. Demonizing THC is just silly, because it’s one of the best, most non-toxic of anti-inflammatories, anti-tumor agents, antioxidants, and neuroprotectants known. And beyond that, almost none of these parents and other patients realize they could fight seizures just as effectively with uncarboxylated THC — that is, tetrahydrocannabinolic acid, THC acid or THCA — as they could with CBD. Furthermore, THCA is no more psychoactive than is CBD, thus allaying parental concerns about getting their children high. No psychoactive effects are experienced from THCA that hasn’t been carboxylated to THC. THCA is one of the cannabinoids primarily found in fresh cannabis, although in variable amounts, according to CannLabs. Once the marijuana plant is exposed to heat — such as when smoking or vaporizing cannabis — THCA decarboxylates to THC (tetrahydrocannabinol), the form that gets you high. What happens on a molecular level is that the carbon dioxide in the cannabis is released, as a carbon atom in the acid gets lost, converting THCA to psychoactive THC. THCA, found in the flowers, leaves, and stems of young cannabis plants, is biosynthesized by the trichomes. It plays a critical role in protecting the trichomes, and thus the plants themselves, from insects and other predators. Although THCA has no psychoactive effects of its own, it acts as a cannabinoid receptor agonist, and in so doing helps in its neuroprotective (brain protection) effects. THCA has also been shown to be an anti-inflammatory agent. It has anti-proliferative qualities that help inhibit the growth of cancerous cells, as well as anti-spasmodic abilities that are useful among epileptic patients. Since THCA works just as well as CBD for seizure control, and THCA is cheaper and more accessible than CBD (especially in the speculative environment created by CBD’s recently skyrocketing popularity), THCA means patient empowerment. In contrast to the specialized, low-THC/high CBD plants needed to make CBD extracts, any high-THC cannabis strain can be used to make THCA tincture. “Any high THC strain can be used,” prominent Australian cannabis breeder/researcher Mark Heinrich told Toke Signals on Monday. “As it is THCA, there is no issue of the high, so that makes strain choice less selective. “Truly, this is universally (read globally) available to even the poorest people,” Heinrich told us. “I have sent the simple method to doctors in India, Pakistan, Bangladesh, and China, with more countries coming. Screen Shot 2014-02-18 at 3.05.23 PM“This is HUGE, and it is so simple,” Heinrich told Toke Signals. “There is no need to spend huge money on CBD if THCA is just as good. “We are getting good results with CBDA, CBD, THCA, and CBN,” Heinrich said. “We are doing great things in Oz, and now being with Dave Mapes has broadened our reach. “Right now, the predators and the sharks are making a killing off CBD, but make no mistake — THCA works just as well and we have proof it does,” Heinrich said. “We want everyone to have access to the tutorials to empower them to be able to make their own and not be reliant on CBD merchants.” What’s even better, the info is FREE, Heinrich told us. “How cool is that, mate? And think how many folks can now get help — empowerment of parents!”
  22. I am posting this firmly in the metaphysics forum because it really isn't going to interest most people but I was very moved by it and wanted to share it somehow. I was privileged to know Rick and some friends made this short film with him and his wife 10 weeks before he passed away in May this year. Rick was a highly driven character who qualified as a doctor and an oncologist with his own clinic. As well as working at this full time and raising a family he also became a very driven seeker in the Zen tradition and then in the modern advaita. 14 years before he died he was diagnosed with lung cancer and this drove him to seek for enlightenment even more strongly until the seeking dropped away (as explained in the film). He was very reconciled to death and handled everything lightly and without fuss – remarkable person. Like I said, not really posting this for haters or debate or anything, just wanted to share it and maybe some people might find it interesting. Rather beautifully made film if nothing else.
  23. A desperate mother has defied conventional medical advice by treating her dying son with cannabis. Little Landon Riddle is three years old and was given just days to live after being diagnosed with leukaemia when he was two. He had several bouts of gruelling chemo and radiotherapy which, although they shrank the tumour, made him very sick. So his mum Sierra has refused to treat her boy with the conventional treatments and is instead using cannabis oil capsules. The oil is a concentrate from the marijuana plant which does not include the psychoactive ingredient THC. "Cannabis, just like morphine, is a medication," said Sierra. "It's not just a drug, it's a medication, and it's a medication that helps my son to fight his cancer." She specifically moved to Colorado Springs in the U.S. to take advantage of the state's marijuana laws. Sierra wrote on her son's Facebook page: "I made the decision to end chemo in mid May. The cannabis has been keeping Landon's cancer in remission, he gets regular lab work and all his counts continue to be outstanding." She went on to say that when meeting with the doctors, they made her feel like she was sentencing her son's to a 'sure death' by not keeping him on steroids and chemo for another three years. She added: "'I am willing to do whatever I have to do to make sure my child gets to live another day and gets to have that relief and have that quality of life he deserves." However, Sierra now faces having Landon taken off her because doctors 'do not see cannabis as a treatment for cancer'. She said: "They want to take my son away and said they have no choice but report her to the police and CPS. "He is responding amazingly to the cannabis, his blood work is immaculate, especially for a cancer patient! How can they not see the proof that is right before their eyes?! Cannabis is fighting his cancer!" The hospital said it cannot comment on individual patients. http://www.parentdish.co.uk/2013/08/29/mum-refuses-chemo-and-gives-cannabis-to-three-year-old-son-to-treat-cancer/