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Found 4 results

  1. Hello uk420 gang, On Sunday at the old age of 24 years old I had a TIA(mini stroke) due to a small bleed on the brain caused by my previous bad habits on party drugs I suspect. Anyway I have been a daily smoker for the past 2 years but I am currently not smoking due to the situation. My question is it safe to keep blazing? I’m pretty uneducated on the effects weed has on a damaged brain but surely it wouldn’t cause any further damage? Should I ditch smoking for a different method of getting that sweet THC? I appreciate any advice or if anyone has been in a similar situation hmu. I have been extremely lucky to only have a small stroke and fully recover I just don’t want to have to give up the herb! Thanks in advance.
  2. Cannabis reverses ageing processes in the brain Researchers at the University of Bonn restore the memory performance of Methuselah mice to a juvenile stage Memory performance decreases with increasing age. Cannabis can reverse these ageing processes in the brain. This was shown in mice by scientists at the University of Bonn with their colleagues at The Hebrew University of Jerusalem (Israel). Old animals were able to regress to the state of two-month-old mice with a prolonged low-dose treatment with a cannabis active ingredient. This opens up new options, for instance, when it comes to treating dementia. The results are now presented in the journal Nature Medicine. Like any other organ, our brain ages. As a result, cognitive ability also decreases with increasing age. This can be noticed, for instance, in that it becomes more difficult to learn new things or devote attention to several things at the same time. This process is normal, but can also promote dementia. Researchers have long been looking for ways to slow down or even reverse this process. Scientists at the University of Bonn and The Hebrew University of Jerusalem (Israel) have now achieved this in mice. These animals have a relatively short life expectancy in nature and display pronounced cognitive deficits even at twelve months of age. The researchers administered a small quantity of THC, the active ingredient in the hemp plant (cannabis), to mice aged two, twelve and 18 months over a period of four weeks. Afterwards, they tested learning capacity and memory performance in the animals – including, for instance, orientation skills and the recognition of other mice. Mice who were only given a placebo displayed natural age-dependent learning and memory losses. In contrast, the cognitive functions of the animals treated with cannabis were just as good as the two-month-old control animals. “The treatment completely reversed the loss of performance in the old animals,” reported Prof. Andreas Zimmer from the Institute of Molecular Psychiatry at the University of Bonn and member of the Cluster of Excellence ImmunoSensation. Years of meticulous research This treatment success is the result of years of meticulous research. First of all, the scientists discovered that the brain ages much faster when mice do not possess any functional receptors for THC. These cannabinoid 1 (CB1) receptors are proteins to which the substances dock and thus trigger a signal chain. CB1 is also the reason for the intoxicating effect of THC in cannabis products, such as hashish or marihuana, which accumulate at the receptor. THC imitates the effect of cannabinoids produced naturally in the body, which fulfil important functions in the brain. “With increasing age, the quantity of the cannabinoids naturally formed in the brain reduces,” says Prof. Zimmer. “When the activity of the cannabinoid system declines, we find rapid ageing in the brain.” To discover precisely what effect the THC treatment has in old mice, the researchers examined the brain tissue and gene activity of the treated mice. The findings were surprising: the molecular signature no longer corresponded to that of old animals, but was instead very similar to that of young animals. The number of links between the nerve cells in the brain also increased again, which is an important prerequisite for learning ability. “It looked as though the THC treatment turned back the molecular clock,” says Zimmer. Next step: clinical trial on humans A low dose of the administered THC was chosen so that there was no intoxicating effect in the mice. Cannabis products are already permitted as medications, for instance as pain relief. As a next step, the researchers want to conduct a clinical trial to investigate whether THC also reverses ageing processes in the brain in humans and can increase cognitive ability. The North Rhine-Westphalia science minister Svenja Schulze appeared thrilled by the study: “The promotion of knowledge-led research is indispensable, as it is the breeding ground for all matters relating to application. Although there is a long path from mice to humans, I feel extremely positive about the prospect that THC could be used to treat dementia, for instance.” Publication: A chronic low dose of delta9-tetrahydrocannabinol (THC) restores cognitive function in old mice, Nature Medicine, DOI: 10.1038/nm.4311 Media contact: Prof. Andreas Zimmer Institute of Molecular Psychiatry University of Bonn Tel. +49 (0)228/6885300 sauce THC good!
  3. Hi guys! Been on this site for years and sorry for the lack of posts. just recently bought a new house and the grow space is slightly smaller than the last and worried about temps with my current 2 x 600w HPS lamps. going to take the plunge to LEDs after a lot of diliberation but it’s really confusing the hell out of me.. so many to choose from and my brain is starting to hurt with all the different info I am seeing.. some swear by LEDs and some say don’t do it! Grow own space is a 2.4m x 1.2m tent. can you guys please let me know the best LED set ups for my grow space please! Hard to trawl through all the posts about LEDs and the best threads seem to be a couple of years out of date.. I just need to know part numbers for the best ones and any other kit I will need to get a fully operational set up going. was looking at DIYLEDs page and all of his kit is out of stock at the moment so was wondering if you guys have any other suggestions? looking to spend £1,000 tops so best options would really be appreciated.. thanks all in advance. SJ
  4. https://www.psychologytoday.com/gb/blog/the-athletes-way/201903/is-your-little-brain-cannabis Increasingly, our “little brain” is being recognized as playing a bigger role than previously thought in cognition, learning, emotions, and addiction. Because human cerebellum has a high density of CB1 cannabinoid receptors, there is speculation that cannabis use most likely affects both cerebellar function and structure. In recent months, two different systematic reviews have done deep and detailed dives into how cannabis affects the cerebellum. The first review, from January 2019, “The Cerebellum, THC, and Cannabis Addiction: Findings from Animal and Human Studies,” was published in The Cerebellum journal. This review (Moreno-Rius, 2019) analyzed previous studies on human subjects and animal models that had identified various ways that cannabis affects the cerebellum. The author of this review also looked at how cannabis-related changes to cerebellar structure and functional connectivity might influence addictive behaviors. Josep Moreno-Rius summed up his findings in the paper’s abstract: A few years ago, I reported on research (Miquel et al., 2015) which identified 'seven arguments for considering' that the cerebellum may be a key player in drug-addiction related brain circuitry. (see "The Cerebellum May Play Unforeseen Role in Driving Addiction") The second recent paper that deconstructs how cannabis influences cerebellum is titled, “Cerebellar Alterations in Cannabis Use: A Systematic Review,” and was published February 27 in Addiction Biology. This analysis was conducted by a team of neuroscientists and addiction specialists from the Netherlands and Spain. After screening a pool of 348 unique papers that addressed the cerebellum-cannabis connection, the reviewers honed in on how cannabis affects the cerebellum and cerebellum-related behavior based on a quantitative analysis of 40 peer-reviewed articles published prior to March 2018. As the authors explain, “We included studies that focused on cannabis effects on cerebellar structure, function, or cerebellar‐dependent behavioral tasks.” The three most consistent findings of this review (Blithikioti et al., 2019) include: Increases in cerebellar gray matter volume after chronic cannabis use Alteration of cerebellar resting state activity after acute or chronic cannabis use Deficits in memory, decision making, and associative learning related to cannabis use As would be expected, the systematic review showed that higher lifelong exposure to cannabis and the younger someone was when he or she started smoking weed—or ingesting marijuana via edibles—was frequently associated with cannabis-induced alterations to cerebellum structure and function. “Chronic cannabis use is associated with alterations in cerebellar structure and function, as well as with deficits in behavioral paradigms that involve the cerebellum (e.g., eyeblink conditioning, memory, and decision making)," Blithikioti and co-authors stated. “Future studies should consider tobacco as confounding factor and use standardized methods for assessing cannabis use. Paradigms exploring the functional activity of the cerebellum may prove useful as monitoring tools of cannabis‐induced impairment." Although both of these reviews (Moreno-Rius, 2019 & Blithikioti et al., 2019) identify a correlation between cannabis use, notable changes to structure/function of the human cerebellum, and addiction—much more research is needed before identifying or assuming causality. by Christopher Bergland References Josep Moreno-Rius. "The Cerebellum, THC, and Cannabis Addiction: Findings from Animal and Human Studies." The Cerebellum (First published online: January 4, 2019) DOI: 10.1007/s12311-018-0993-7 Chrysanthi Blithikioti, Laia Miquel, Albert Batalla, Belen Rubio, Giovanni Maffei, Ivan Herreros, Antoni Gual, Paul Verschure, Mercedes Balcells‐Oliveró. "Cerebellar Alterations in Cannabis Users: A Systematic Review." Addiction Biology (First published online: February 27, 2019) DOI: 10.1111/adb.12714 Josep Moreno-Rius, Marta Miquel. "The Cerebellum in Drug Craving." Drug and Alcohol Dependence (First published online: February 20, 2017) DOI: 10.1016/j.drugalcdep.2016.12.028 Marta Miquel, Dolores Vazquez-Sanroman, María Carbo-Gas, Isis Gil-Miravet, Carla Sanchis-Segura, Daniela Carulli, Jorge Manzo, Genaro A. Coria-Avila. "Have We Been Ignoring the Elephant in the Room? Seven Arguments for Considering the Cerebellum as Part of Addiction Circuitry." Neuroscience & Biobehavioral Reviews (First published online: November 19, 2015) DOI: 10.1016/j.neubiorev.2015.11.005