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Vapour Heads

Vapourizing hints, tips and discussions.

789 topics in this forum

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  • Posts

    • blackpoolbouncer
      In your setting that's fine mate.    Would be a lot of wasted space I doors though. You want like a good solid foot of buds to form a canopy.   Light penetrates so a canopy can be thicker than a branch laid flat.    The first pic in my post above shows what I like to aim for.  Think of the colas like bottles lined up. You've just got them all lined up but sat on their sides. Even better if you have space. You will get no airy bud at all.    Id leave that be and be happy with how that plant has formed and give myself a pat on the back for doing a good job. Well done mate 
    • twigs
      The authors detailed the evidence for how cannabis’ anti-inflammatory powers may help in a peer reviewed article in this month’s issue of Brain, Behavior, and Immunity   SARS-CoV2 induced respiratory distress: Can cannabinoids be added to anti-viral therapies to reduce lung inflammation Siddappa N. Byrareddy and Mahesh Mohan Additional article information Coronavirus disease-2019 (COVID-19), caused by Severe Acute Respiratory Syndrome coronoavirus-2 (SARS-CoV2) has emerged as a global pandemic, which was first reported in Wuhan, China. Recent reports have suggested that acute infection is associated with a cytokine superstorm, which contributes to the symptoms of fever, cough, muscle pain and in severe cases bilateral interstitial pneumonia characterized by ground glass opacity and focal chest infiltrates that can be visualized on computerized tomography scans (Rothan and Byrareddy, 2020). Currently, there are no effective antiviral drugs or vaccines against SARS-CoV2. In the recent issue of BBI, Zhang et al. (Zhang et al., 2020) thoroughly summarized the current status of potential therapeutic strategies for COVID-19. One of them, anti-IL6 receptor (Tocilizumab) antibody, resulted in clearance of lung consolidation and recovery in 90% of the 21 treated patients (Fu et al., 2020). Although promising, it has also produced adverse effects like pancreatitis and hypertriglyceridemia (Morrison et al., 2020), which make it imperative to explore effective alternative anti-inflammatory strategies. Here, we intend to highlight the potential effects of cannabinoids, in particular, the non-psychotropic cannabidiol (CBD), that has shown beneficial anti-inflammatory effects in pre-clinical models of various chronic inflammatory diseases and is FDA approved for seizure reduction in children with intractable epilepsy (Nichols and Kaplan, 2020).   Like Δ9-tetrahydrocannabinol (Δ9-THC), the most well-studied cannabinoid, CBD decreased lung inflammation in a murine model of acute lung injury potentially through the inhibition of proinflammatory cytokine production by immune cells and suppressing exuberant immune responses (Ribeiro et al., 2015). CBD can inhibit the production of proinflammatory cytokines like interleukin (IL)-2, IL-6, IL-1α and β, interferon gamma, inducible protein-10, monocyte chemoattractant protein-1, macrophage inflammatory protein-1α, and tumor necrosis factor-α (Nichols and Kaplan, 2020) (Fig. 1 ) that have been associated with SARS-CoV2 induced multi-organ pathology and mortality. In a murine model of chronic asthma, CBD reduced proinflammatory cytokine production, airway inflammation and fibrosis (Vuolo et al., 2019). Moreover, CBD can effectively inhibit the JAK-STAT pathway including the production and action of type I interferons without leading to addiction, alterations in heart rate or blood pressure and adverse effects on the gastrointestinal tract and cognition (Nichols and Kaplan, 2020). In simian immunodeficiency virus (SIV)-infected rhesus macaques (RMs), we reported THC mediated attenuation of IFN stimulated gene expression in the intestine (Kumar et al., 2019). Similar to CBD, chronic THC administration blocked inflammation induced fibrosis in lymph nodes of chronically SIV-infected RMs (Kumar et al., 2019). Unlike THC, CBD has a high margin of safety and is well tolerated pharmacologically even after treatments of up to 1500 mg/day for two weeks in both animals and humans (Nichols and Kaplan, 2020), which suggests its feasibility to reduce SARS-CoV2 induced lung inflammation/pathology and disease severity.   The many uncertainties associated with the COVID-19 pandemic such as status of the economy, employment and loss of connection can fuel depression, fear and anxiety. CBD has shown promise as an alternative therapy for the clinical management of anxiety disorders (Nichols and Kaplan, 2020). Based on its anxiolytic and anti-depressant properties, it has been suggested that CBD could be used to improve the mental and somatic health of patients suffering from anxiety and emotional stress after recovering from Ebola disease (Reznik et al., 2016). Like Ebola, patients recovering from COVID-19 may experience various psychological and social stressors that may be triggered by residual chronic inflammation and autoimmune reactions. Therefore, randomized clinical trials to test the efficacy of CBD on alleviating anxiety and fear associated with COVID-19 infection and its consequences on people’s physical, social and psychological well-being may be beneficial in the future. Additionally, severely ill COVID-19 patients exhibited neurological symptoms like cerebrovascular disease, headache and disturbed consciousness (Reviewed in (Wu et al., 2020)). Brain edema, neuronal degeneration and presence of SARS-CoV2 in the cerebrospinal fluid (CSF) were confirmed at autopsy (Wu et al., 2020). Therefore, longitudinal CSF sampling using non-human primate (NHP) studies may help clarify whether and when SARS-CoV2 invades the brain, and if this happens, does it result in neuroinflammation and more importantly, whether cannabinoids can modulate these events (Kumar et al., 2019). Being a negative allosteric modulator of the cannabinoid receptor-1, CBD can counter the psychotropic effects of THC when co-administered with THC (Nichols and Kaplan, 2020). Although Remdesivir reduced the mortality rate of seriously ill COVID-19 patients needing invasive ventilation (Zhang et al., 2020), similar studies in rhesus macaques revealed minimal subpleural inflammatory cellular infiltrates in the lungs of clinically recovered Remdesivir treated RMs at necropsy (Williamson et al., 2020). This suggests persistence of inflammation and may partly explain the 20–30% reduction in lung function in COVID-19 patients after recovery, which if left unresolved may lead to pulmonary fibrosis. Collectively, these findings support the investigation of cannabinoids as a plausible option to be added as an adjunct to Remdesivir or any new antivirals on SARS-CoV2 induced lung inflammation. This work was supported by the National Institutes of Health Award Numbers R01DA042524, R01DA050169 and R56DE026930 to MM, and P51OD0111133. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Article information Brain Behav Immun. 2020 Jul; 87: 120–121.  Published online 2020 Apr 28. doi: 10.1016/j.bbi.2020.04.079 PMCID: PMC7187842 PMID: 32360437 Siddappa N. Byrareddya and  Mahesh Mohanb,⁎ aDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, United States bTexas Biomedical Research Institute, Southwest National Primate Research Center, San Antonio, TX 78227, United States Siddappa N. Byrareddy: ude.cmnu@ydderaryb.dis; Mahesh Mohan: gro.demoibxt@nahomm ⁎Corresponding author at: Texas Biomedical Research Institute, Southwest National Primate Research Center, 8715 West Military Road, San Antonio, TX 78258, United States. gro.demoibxt@nahomm Received 2020 Apr 27; Accepted 2020 Apr 27. Keywords: SARS-CoV2, Rhesus macaque, Cannabinoids, Inflammation, Cytokine, Lung   here  
    • 420Chimp
      Thanks for the reply, that makes sense so if I use the following as an example, I should probably have stopped LST a bit ago to allow for the branches to thicken up together?    My main each time now there's no new growth sites is to get direct sunlight on the bud sites. Each time they reach back straight and blocks the sites below then I'll bend again. For example the main cola (after this pic) got bent over pretty much horizontally so the light would directly hit side of all the sites rather than some being blocked by leaves/shade. I'd of been better leaving it earlier and allowing it to grow taller?   
    • Tomasz
      Hi I'm 2 week in to flowering and find one plant is male with many sacks of polen already open I took I away but polen is already all over my female plants  What can I do know?  If I keep these female they will produce female seeds or just weed full of seeds?  Or just is not worth and Throw it away?